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Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels.

• William J. Hadden, Jennifer Young, +13 authors Yu Suk Choi
• Proceedings of the National Academy of Sciences…
• 2017

The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the differential diffusion distance of unreacted… (More)

Imaging modalities in the diagnosis of pancreatic adenocarcinoma: A systematic review and meta-analysis of sensitivity, specificity and diagnostic accuracy.

• James Toft, William J. Hadden, +4 authors Henry C. C. Pleass
• European journal of radiology
• 2017

BACKGROUND Pancreatic cancer, primarily pancreatic ductal adenocarcinoma (PDAC), accounts for 2.4% of cancer diagnoses and 5.8% of cancer death annually. Early diagnoses can improve 5-year survival… (More)

Limitations in predicting outcome following primary ACL reconstruction with single-bundle hamstring autograft - A systematic review.

• Vincent Vg An, Corey J. Scholes, Vikram Arun Mhaskar, William J. Hadden, David Parker
• The Knee
• 2017

BACKGROUND Anterior cruciate ligament reconstruction (ACLR) is one of the most well studied and performed procedures in the world. Thus, it would be useful to develop a tool to predict patient… (More)

Resection of colorectal liver metastases and extra-hepatic disease: a systematic review and proportional meta-analysis of survival outcomes.

• William J. Hadden, Philip R. de Reuver, Kai M. Brown, Anubhav Mittal, Jaswinder Singh Samra, T. J. Hugh
• HPB : the official journal of the International…
• 2016

BACKGROUND Colorectal cancer (CRC) accounts for 9.7% of all cancers with 1.4 million new cases diagnosed each year. 19-31% of CRC patients develop colorectal liver metastases (CRLM), and 23-38%… (More)

The extracellular microscape governs mesenchymal stem cell fate

• William J. Hadden, Yu Suk Choi
• Journal of biological engineering
• 2016

Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain… (More)

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