William J Vicic

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Density-related subpopulations of platelets were obtained by centrifuging platelets obtained from venous blood on a discontinuous gradient of arabinogalactan (Stractan). Four subpopulations were obtained in fractions of the gradient with densities less than or equal to 1.058, 1.065, 1.070, and 1.092 g/ml. The percentage of the total platelet population(More)
Four members (from four generations) of a family with a mild bleeding disorder and intermittent thrombocytopenia had decreased plasma levels of properties related to factor VIII/von Willebrand factor (FVIII/VWF), an absence of high-molecular-weight forms of FVIII/VWF in the plasma (but normal multimeric structure in the platelets), and increased(More)
This is a study of a 34 year old woman with a moderate to severe bleeding disorder in whom impaired platelet procoagulant activity (PPA) was found by several methods, including tests of factor 3 availability (PF-3a), prothrombin consumption and contact activation. No deficiencies of platelet adhesion, aggregation, secretion, metabolism or granule-bound(More)
Studies on platelet dense granule structure were carried out in 20 patients with various types of congenital storage pool deficiency (SPD), including 15 with specific deficiencies of dense granules and dense granule substances (delta-SPD), and five with combined deficiencies of dense and alpha-granules (alpha delta-SPD). Dense granules were identified by(More)
Health care is generally unavailable for the homeless. This heterogeneous group of men and women, including long-term street dwellers, residents of shelters, the chronically mentally ill, the economically debased, and alienated youth, are subject to a broad range of acute and chronic diseases, intensified by unsuitable living conditions, stress, and(More)
Patients with aortic stenosis are subject to recurrent episodes of gastrointestinal bleeding of uncertain cause. How such patients should be handled when aortic valve replacement is required is not established. This report deals with such a patient who underwent successful aortic valve replacement with a porcine xenograft without anticoagulation. The(More)