William J. Sheehan

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BACKGROUND Cow's milk allergy is the most common food allergy in childhood. Many children with IgE-mediated cow's milk allergy may tolerate baked milk products, but few data exist on predictors of outcomes of baked milk challenges. OBJECTIVE To determine the relation of milk protein allergen specific IgE (sIgE) levels and skin prick test (SPT) wheal size(More)
Previous studies suggest that children with egg allergy may be able to tolerate baked egg. Reliable predictors of a successful baked egg challenge are not well established. We examined egg white-specific IgE levels, skin-prick test (SPT) results, and age as predictors of baked egg oral food challenge (OFC) outcomes. We conducted a retrospective chart review(More)
BACKGROUND Most studies of indoor allergens have focused on the home environment. However, schools may be an important site of allergen exposure for children with asthma. We compared school allergen exposure to home exposure in a cohort of children with asthma. Correlations between settled dust and airborne allergen levels in classrooms were examined. (More)
BACKGROUND The association between allergens in schools and childhood asthma has not been well studied, particularly in the United States. OBJECTIVE To investigate allergen exposure in schools compared with homes with a specific focus on children with asthma. METHODS Dust samples were collected from 46 rooms in 4 urban elementary schools (northeastern(More)
T he treatment of eczema in the pediatric population can be a complex and dynamic process. A typical careplanmay includeover-the-counter andprescription topical agents, oral medications, as well as bathing and dietary recommendations. Inevitable disease fluctuations demand treatment modification, and thus parental and patient confusion can easily occur. Not(More)
BACKGROUND Children with egg allergy may tolerate baked egg products. Ovomucoid specific IgE (sIgE) antibody levels have been suggested to predict outcomes of baked egg challenges. OBJECTIVE We determined the relationship of ovomucoid and egg white sIgE levels and egg white skin prick test (SPT) wheal size with baked egg challenge outcome. METHODS(More)
BACKGROUND Endotoxins are stimulators of the immune system and, despite their potential to protect against allergy, have been associated with early wheezing and asthma morbidity. OBJECTIVE To compare inner-city school endotoxin exposure with home endotoxin exposure in children with asthma. METHODS Students with asthma were recruited from 12 urban(More)
IMPORTANCE Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to illness pathogenesis. Strategies that effectively attenuate such episodes are needed. OBJECTIVE To evaluate if early administration of azithromycin, started prior to(More)
PURPOSE OF REVIEW The aim of the present review was to discuss the epidemiology of inadequate asthma control with an examination of contributing environmental factors. RECENT FINDINGS Despite advances in asthma therapies, a proportion of patients with asthma continue to have difficulty in gaining adequate asthma control. Asthma severity and control in(More)