William J. Pizzi

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Pharmacologic agents with a potential to attenuate the reinforcing properties of drugs of abuse may have an important role in the treatment of drug addiction. The reduction of drug self-administration and sweet solution intake are two common animal models employed to screen for promising therapeutic agents. When these agents are effective in suppressing the(More)
Pregnant Sprague-Dawley rats were administered sodium diphenylhydantoin (DPH) by gavage on gestation days 9-18 in doses of 0, 100, or 200 mg/kg. DPH-treated dams showed a dose-related decrease in weight gain throughout the drug treatment period. Offspring had significantly lowered birth weights, along with increased mortality through the first 30 days of(More)
Prenatal exposure to psychotropic drugs has recently been shown to induce behavioral and brain neurochemical changes in the newborn. The long-term effects of pre- and postnatal exposure to methadone on the opioid (delta and mu) and adrenergic (alpha 2) receptors were investigated in two areas of the rat brain. Rat pups received prenatal treatment with(More)
Monosodium glutamate (MSG) administered during the neonatal period (days 2 to 11) resulted in a sequence of events that were manifested in adulthood. Reproductive dysfunction was seen in both female and male animals. Females treated with MSG had fewer pregnancies and smaller litters, while males treated with MSG showed reduced fertility. The MSG-treated(More)
The evolution-creation debate continues to evoke passionate arguments as the competing epistemological systems of theology and science clash. Recent legal challenges in Dover, PA and renewed attempts to insert some form of creationism into the Kansas curriculum are representative of current events. In Dover, the school board voted to add an Intelligent(More)
We conducted a randomized, double-blind, placebo-controlled crossover study of folinic acid therapy (dl-Leucovorin, 15 mg/day) or placebo for males with Fragile X (fra(x)) syndrome. Twenty-one patients were enrolled in the study. The treatment periods were 3 months in length. Patients were followed with chemistry panels and complete blood counts. No(More)
Neonatal mice 1 and 5 days of age and older mice 25 days of age were injected with an increasing dose of monosodium glutamate (MSG) for a ten-day period and observed for at least 150 days. Both male and female animals in the 1- and 5-day age group treated with MSG showed large increases in weight over controls along with a shortened body length. The MSG(More)
BACKGROUND The fragile X gene contains an unstable trinucleotide (CGG) repeat that expands as it is passed from female carriers to the affected offspring. Obligate female carriers may have a premutation or full mutation genotype. METHODS In this study, fragile X premutation and full mutation female carriers were compared on three tasks of visual(More)
BACKGROUND Oculo-visual findings commonly associated with persons diagnosed as having mental illness and/or dual diagnosis (i.e. mental illness with mental retardation) have not been fully investigated. This study determines the most common eye and vision anomalies associated with these disorders and discusses the similarities and differences between these(More)