William J. Marshall

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At one time, risk management meant buying corporate insurance, implementing procedures to avoid lawsuits and accidents, and installing safety equipment. The new risk management uses financial markets to hedge different sources of risk within the firm. Trading in financial markets can hedge companies against the risk of changes in interest rates, input(More)
Increasing evidence supports the notion that both internalizing (e.g., anxiety) and externalizing (e.g., aggression) behavioral dysregulation are associated with abnormal communication between brain regions. Electroencephalographic (EEG) signals across two electrode sites are said to be coherent with one another when they show consistent phase relations.(More)
Cortical activity is maintained by neural networks working in tandem. Electroencephalographic (EEG) signals across two sites are said to be coherent with one another when they show consistent phase relations. However, periods of desynchrony beginning with a shift in phase relations are a necessary aspect of information processing. Traditional measures of(More)
We consider the problem of change-point estimation of the instantaneous phase of an observed time series. Such change points, or phase shifts, can be markers of information transfer in complex systems; their analysis occurring in geology, biology and physics, but most notably in neuroscience. We develop two non-parametric approaches to this problem: the(More)
The syntheses and rat CRF receptor binding affinities of 'retro-pyrazolotriazine' corticotropin-releasing factor (CRF) ligands 4 are reported. Some have high affinity for rat CRF receptors (K(i)< or =10 nM). The data provide additional support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the(More)
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