William J. Mackillop

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CONTEXT Adjuvant chemotherapy (AC) improves survival among patients with resected colorectal cancer. However, the optimal timing from surgery to initiation of AC is unknown. OBJECTIVE To determine the relationship between time to AC and survival outcomes via a systematic review and meta-analysis. data sources: MEDLINE (1975 through January 2011), EMBASE,(More)
BACKGROUND Associations between socioeconomic status (SES) and the incidence of cancer have been reported previously in the U.S. Canada has more comprehensive health care and social programs than the U.S. The purpose of this study was to compare the strength of associations between SES and cancer incidence in Canada and the U.S. METHODS The regions(More)
BACKGROUND Numerous studies to date have suggested an association between radiation exposure and the development of soft tissue sarcoma. The current study was performed to quantify the risk of soft tissue sarcoma in the vicinity of previously irradiated anatomic regions in women with breast carcinoma. METHODS In this population-based, retrospective cohort(More)
STUDY OBJECTIVES To provide a systematic overview of the literature investigating patient and tumor factors that are predictive of survival for patients with non-small cell lung cancer (NSCLC), and to analyze patterns in the design of these studies in order to highlight problematic aspects of their design and to advocate for appropriate directions of future(More)
PURPOSE This study was designed to determine what questions health-care professionals think should be addressed with curable prostate cancer patients before treatment decisions are made. METHOD A survey was distributed to radiation oncologists, urologists, medical oncologists, nurses and radiation therapy technologists (RTTs) involved in treating prostate(More)
PURPOSE To determine the questions that recently diagnosed early-stage prostate cancer patients think should be addressed with patients like themselves. STUDY POPULATION 56 patients diagnosed as having early-stage prostate cancer within the previous year. METHODS Surveys distributed to the patients included 93 questions that might be considered(More)
PURPOSE The objective of this study was to synthesize what is known about the relationship between delay in radiotherapy (RT) and the outcomes of RT. METHODS A systematic review of the world literature was conducted to identify studies that described the association between delay in RT and the probability of local control, metastasis, and/or survival.(More)
PURPOSE To compare the risk for fatal myocardial infarction (MI) after adjuvant radiotherapy (RT) for left-sided breast cancer with the risk for MI after adjuvant RT for right-sided breast cancer. METHODS We studied women with local- and regional-stage breast cancer diagnosed from 1973 to 1992 from the Surveillance, Epidemiology, and End-Results (SEER)(More)
PURPOSE The objective of this study was to estimate the effect of delay in initiation of treatment on rates of local control by radiotherapy. METHODS AND MATERIALS A model of the effects of delay was developed based on the following assumptions: (a) that tumor growth rate is exponential, (b) that a predetermined radiotherapy regimen will kill the same(More)
INTRODUCTION People with lower socioeconomic status (SES) experience shorter survival times after a cancer diagnosis for many disease sites. We determined whether area-level SES was associated with the outcomes: cause-specific survival and local-regional failure in laryngeal cancer in Ontario, Canada. When we found an association we sought explanations that(More)