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The purpose of this study was to determine the sensitivity of discourse gist measures to the early cognitive-linguistic changes in Alzheimer disease (AD) and in the preclinical stages. Differences in discourse abilities were examined in 25 cognitively normal adults, 24 adults with mild probable AD, and 20 adults with mild cognitive impairment (MCI) at gist(More)
William Frawley's original and wide-ranging new book embraces linguistics, artificial intelligence, philosophy, and psychology in seeking a reconciliation between contemporary cognitive science and Vygotskian psychology. Lev Semenovich Vygotsky (1896-1934) was a Russian psychologist who founded the sociocultural school of psychology, which is based upon the(More)
Computers have promised us a fountain of wisdom but delivered a flood of data-A frustrated MIS executive Abstract This chapter presents an overview of the state of the art in research on knowledge discovery in databases. We analyze !{ now ledge Discovery and define it as the nontrivial extraction of implicit , previously unknown , and potentially useful(More)
BACKGROUND Thalamic deep brain stimulation ameliorates essential and parkinsonian tremors refractory to medications. Stimulus voltage, polarity configuration, frequency, and pulsewidth can each be adjusted in order to optimize tremor control and maximize battery life. The relative impacts of these programmable variables have not previously been quantified.(More)
Myeloperoxidase (MPO) is a major enzyme found in neutrophils. Oxidation by MPO produces free radicals that demonstrate genotoxic properties. A polymorphism (G to A) within the promotor region of the MPO gene reduces transcription and expression. This polymorphism is associated with a protective effect against some cancers in adults including lung cancer.(More)
BACKGROUND There is a poor correlation between multiple sclerosis disease activity, as measured by magnetic resonance imaging, and clinical disability. OBJECTIVE To establish oculographic criteria for the diagnosis and severity of internuclear ophthalmoparesis (INO), so that future studies can link the severity of ocular dysconjugacy with(More)
This paper presents a processing theory of alexithymia in terms of failure of report across the components of emotional processing and the nature of explicit and implicit knowledge. The typical features of alexithymia (e.g., failure of cue recognition, flattened expression, inability to articulate emotional states) correspond to disruptions at the(More)
In prior work from this laboratory, we have examined how accurately subjects can judge collinearity, i.e. alignment, as a function of the angular position of stimulus elements. In those experiments, subjects were presented with a line segment (or a pair of dots) which varied across the 360 degrees range of angular positions, and were required to select and(More)
Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects. Mice fed DHEA (0.45% w/w of food) and mice pair-fed to these mice (food restricted) for 8 weeks were tested for changes in(More)