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BACKGROUND Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed to contain information about the(More)
Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automated seizure detection and prediction(More)
BACKGROUND Expert knowledge in journal articles is an important source of data for reconstructing biological pathways and creating new hypotheses. An important need for medical research is to integrate this data with high throughput sources to build useful models that span several scales. Researchers traditionally use mental models of pathways to integrate(More)
Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory mechanisms. We evolve an integrated generic cell network to represent the connectivity of key cellular mechanisms structured into positive and(More)
Highly-resolved simulations of groundwater ow, chemical migration , and contaminant recovery processes are used to test the applicability of stochastic models of ow and transport in a typical eld setting. A simulation domain encompassing a portion of the upper saturated aquifer materials beneath the Lawrence Livermore National Laboratory was developed to(More)
BACKGROUND Autosomal dominant (AD) diseases result when a single mutant or non-functioning gene is present on an autosomal chromosome. These diseases often do not emerge at birth. There are presently two prevailing theories explaining the expression of AD diseases. One explanation originates from the Knudson two-hit theory of hereditary cancers, where loss(More)
BACKGROUND Non-adherence to prescribed medications is a serious health problem in the United States, costing an estimated $100 billion per year. While poor adherence should be addressable with point of care health information technology, integrating new solutions with existing electronic health records (EHR) systems require customization within each(More)
The commentary by professors Griffin and Westbury [1] seems to be a response to the widespread media coverage following the recent publication of our article [2]. Most of the media coverage was accurate and carefully emphasized that, while our new approach to measuring early brain development might be promising for detecting risk for disorders such as(More)