William J. Anderson

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In the autoradiograms of young rats injected with thymidine-H3 many of the granule cells of the dentate gyrus were found labeled. The number of labeled cells declined rapidly with increased age at the time of injection. Histological studies showed the presence in young rats of a large germinal matrix of mitotic cells in the ependymal and subependymal layers(More)
Amyloid beta(1-42), a major component of amyloid plaques, binds with exceptionally high affinity to the alpha 7 nicotinic acetylcholine receptor and accumulates intracellularly in neurons of Alzheimer's disease brains. In this study, we investigated the possibility that this binding plays a key role in facilitating intraneuronal accumulation of amyloid(More)
A full description of the ontogeny of the beta cell would guide efforts to generate beta cells from embryonic stem cells (ESCs). The first step requires an understanding of definitive endoderm: the genes and signals responsible for its specification, proliferation, and patterning. This report describes a global marker of definitive endoderm, Claudin-6(More)
Scientists constantly make groundbreaking discoveries, some of which receive attention from the press. We designed a course intended for a lay audience that provides the scientific background to appreciate these reports more fully. We discuss three topics in the life sciences: stem cells, cancer, and infectious disease. The course is structured to blend(More)
ii This dissertation is dedicated to my family: my dad, Phil Van Noord my mom, Betty Van Noord and my siblings, spouses and their kids: Also to my fiancée Annabel Cutland. You have been a true blessing through this whole experience. Dedicated foremost to God, you have designed an amazing universe. iii ACKNOWLEDGMENTS Several people have helped me with this(More)
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