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In the autoradiograms of young rats injected with thymidine-H3 many of the granule cells of the dentate gyrus were found labeled. The number of labeled cells declined rapidly with increased age at the time of injection. Histological studies showed the presence in young rats of a large germinal matrix of mitotic cells in the ependymal and subependymal layers(More)
Amyloid beta(1-42), a major component of amyloid plaques, binds with exceptionally high affinity to the alpha 7 nicotinic acetylcholine receptor and accumulates intracellularly in neurons of Alzheimer's disease brains. In this study, we investigated the possibility that this binding plays a key role in facilitating intraneuronal accumulation of amyloid(More)
The finding of motoneuron dendrites organized into small compact bundles in cats, monkeys and pigs suggested that a study of this phenomenon in rats should be undertaken. An analysis was performed with electron microscopy, light microscopy and Golgi methods. An extensive dendrite bundle organization was found in the sixth lumbar segment of the spinal cord.(More)
The postnatal development of the ventrolateral dendrite bundle (LDB) in the rat lumbosacral cord was studied quantitatively with Golgi-Cox impregnation. At birth, motoneuronal perikarya and their dendrites were not fully developed, and had not begun to form bundles; varicose dendritic shafts radiated symmetrically from motoneurons. Dendrites contained(More)
A full description of the ontogeny of the beta cell would guide efforts to generate beta cells from embryonic stem cells (ESCs). The first step requires an understanding of definitive endoderm: the genes and signals responsible for its specification, proliferation, and patterning. This report describes a global marker of definitive endoderm, Claudin-6(More)
Cortical pyramidal cell development was studied in postnatally lead-exposed kittens by light microscopic and Golgi staining methods. The most evident finding was an elevation of spine density on the distal apical dendritic branches of lead-treated kittens. Also, the branching pattern of the apical dendrites in lead-treated animals was different from(More)
Many investigations have sought to determine the effect of lead exposure on the development of the cerebellum. This study addresses the effects of postnatal lead exposure in kittens on dendritic development of Purkinje cells. Golgi-Cox filled cells were used to measure dendritic branching patterns, spine density, height, width and distance from the(More)
Postnatal formation of the ventromedial dendrite bundle (MDB) in the rat lumboscral cord was examined quantitatively with Golgi-Cox impregnation. At birth, dendrites of motoneurons in the MDB had not achieved their total length, and had not begun to form bundles. Dendrites projected from the soma in a radially symmetric fashion. At 5 days, dendritic shafts(More)