William I Rosenblum

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BACKGROUND AND PURPOSE Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcirculation and to examine the relationship(More)
Microfabrication technology, more commonly applied to the manufacture of integrated circuits, can be used to build devices useful for mechanical delivery of drugs and genes. Microprobes fabricated using silicon micromachining have been used to deliver DNA into cells as an alternative to bombardment and microinjection. This idea can be extended to(More)
This review describes histopathologic observations made with both light and electron microscopy using both conventional staining techniques and histochemistry. Several conditions are analyzed: Ischemic cell change; delayed neuronal death; selective vulnerability. The histopathologic support for the calcium hypothesis and for the excitotoxic hypothesis(More)
Cytotoxic edema (CytE) is an increment in total brain water produced when the excess water swells cells rather than expanding the extracellular space. CytE contributes to brain swelling with a resultant increase of intracranial pressure (ICP). However, questions remain concerning the magnitude of the contribution made by CytE to raised ICP and the ability(More)
The effects of accommodation demand and deprivation on the development of ocular optics was investigated in four groups of kittens (total n = 29). Group 1 consisted of five normal kittens; group 2 (nine kittens) had monocular radial keratotomy to induce relative hypermetropia and more accommodation demand as well as to impart interocular refractive(More)
Traumatic brain injury may result in immediate long-lasting coma. Much attention has been given to predicting this outcome from the initial examination because these predictions can guide future treatment and interactions with the patient's family. Reports of diffuse axonal injury in these cases have ascribed the coma to widespread damage in the deep white(More)
Midbrain lesions were found in 23 of 35 autopsied, head-injured people. These lesions were interpreted as "primary"--that is, occurring at the time of impact. This interpretation was concordant with the clinical data, although the difficulty in establishing the precise moment at which the lesions were initiated in any individual case was recognized.(More)
Interest in the A beta amyloid in Alzheimer disease (AD) has largely focused on the A beta in the neuropil, an extracellular site. Here much attention has been given to the possibility that A beta acts as a neurotoxin. However, increasing emphasis is now being given to the relationship between neurofibrillary tangles (NFT) and the degree of cognitive(More)