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We present the application of a nonrandom sequence-tagged site (STS) content detection method in mapping an entire genome, that of fission yeast. The novelty of our strategy is in the use of STS probes made from both ends of cosmid clones, selected on the basis of "sample without replacement" (only library clones that show no previous positive hybridization(More)
The Chinese language search engine Baidu.com is the fourth most trafficked web site in the world, in what will likely soon become the world's largest user-base, China. We will outline three key systems: search engine, iknow.baidu.com, and advertising platform, and describe open problems encountered in the continuing process to improve Baidu.com's technology(More)
Mutations have been generated at the Lys84 site of the lac repressor to explore its predicted role in inducer binding and/or subunit interaction. Four single mutations, Lys84-->Ala, Lys84-->Leu, Lys84-->Arg, and Lys84-->Glu, have been generated by site-specific mutagenesis. In addition, the mutation Tyr282-->Asp, which results in a monomeric repressor, has(More)
To explore the roles of three aspartate residues, Asp88, Asp130, and Asp274, found in the proposed inducer binding site of lac repressor [Sams, C. F., Vyas, N. K., Quiocho, F. A., & Matthews, K. S. (1984) Nature 310, 429-430], each site was substituted with alanine, glutamate, lysine, or asparagine by site-specific mutagenesis. The mutations at the Asp88(More)
Many database applications require similarity based retrieval on stored text and/or multimedia objects. This is an area of increasing research interest in the sectors of database, data mining, information retrieval and knowledge discovery. This paper presents a brief survey on the existing approximate string matching algorithms by primarily demonstrating(More)