William Housley

Learn More
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmune diseases from genotyping data. We integrated these predictions with transcription and cis-regulatory(More)
BACKGROUND Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than(More)
Taylor & Francis makes every effort to ensure the accuracy of all the information (the " Content ") contained in the publications on our platform. Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Versions of published Taylor &(More)
Novel phosphorylated dihydroceramide (PDHC) lipids produced by the periodontal pathogen Porphyromonas gingivalis include phosphoethanolamine (PE DHC) and phosphoglycerol dihydroceramides (PG DHC) lipids. These PDHC lipids mediate cellular effects through Toll-like receptor 2 (TLR2) including promotion of IL-6 secretion from dendritic cells and inhibition of(More)
Social media platforms provide an increasingly popular means for individuals to share content online. Whilst this produces undoubted societal benefits, the ability for content to be spontaneously posted and reposted creates an ideal environment for rumour and false/malicious information to spread rapidly. When this occurs it can cause significant harm and(More)
The last 5--10 years have seen a massive rise in the popularity of social media platforms such as Twitter, Facebook, Tumblr etc. These platforms enable users to post and share their own content instantly, meaning that material can be seen by multiple others in a short period of time. The growing use of social media has been accompanied by concerns that(More)
The increasing popularity of social media platforms such as Facebook, Twitter, Instagram and Tumblr has been accompanied by concerns over the growing prevalence of 'harmful' online interactions. The term 'digital wildfire' has been coined to characterise the capacity for provocative content on social media to propagate rapidly and cause offline harm. The(More)
  • 1