William Housley

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Little is currently known about the factors that promote the propagation of information in online social networks following terrorist events. In this paper we took the case of the terrorist event in Woolwich, London in 2013 and built models to predict information flow size and survival using data derived from the popular social networking site Twitter. We(More)
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmune diseases from genotyping data. We integrated these predictions with transcription and cis-regulatory(More)
BACKGROUND Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than(More)
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Novel phosphorylated dihydroceramide (PDHC) lipids produced by the periodontal pathogen Porphyromonas gingivalis include phosphoethanolamine (PE DHC) and phosphoglycerol dihydroceramides (PG DHC) lipids. These PDHC lipids mediate cellular effects through Toll-like receptor 2 (TLR2) including promotion of IL-6 secretion from dendritic cells and inhibition of(More)
Social media platforms provide an increasingly popular means for individuals to share content online. Whilst this produces undoubted societal benefits, the ability for content to be spontaneously posted and reposted creates an ideal environment for rumour and false/malicious information to spread rapidly. When this occurs it can cause significant harm and(More)
During the course of this paper we examine publically available social media data that relates to the London 2012 Olympic Games that has been harvested and analysed using the Cardiff Online Social Media ObServatory (COSMOS). Social media has matured sufficiently in terms of user uptake and incorporation into traditional media platforms and outlets that the(More)
The last 5--10 years have seen a massive rise in the popularity of social media platforms such as Twitter, Facebook, Tumblr etc. These platforms enable users to post and share their own content instantly, meaning that material can be seen by multiple others in a short period of time. The growing use of social media has been accompanied by concerns that(More)
Astrocytes are key players in the pathology of multiple sclerosis and can assume beneficial and detrimental roles during lesion development. The triggers and timing of the different astroglial responses in acute lesions remain unclear. Astrocytes in acute multiple sclerosis lesions have been shown previously to contain myelin debris, although its(More)
Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selectively(More)