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Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of host cells. Previously, we have found that C. albicans hyphae invade endothelial cells and oral epithelial cells in vitro by inducing their own endocytosis. Therefore, we set out to identify(More)
Bacterial capsules are common targets for antibody-mediated immunity. The capsule of Bacillus anthracis is unusual among capsules because it is composed of a polymer of poly-γ-d-glutamic acid (γdPGA). We previously generated murine IgG3 monoclonal antibodies (mAbs) to γdPGA that were protective in a murine model of pulmonary anthrax. IgG3 antibodies are(More)
IN November, 1891, one of us (Welch ~), at a meeting of the Johns Hopkins Hospital Medical Society, reported with demonstrations the discovery of a gas-forming bacillus found in the eml)hysematous tissues and blood of a man dead of aneurism of the aorta. In July-August, 1892, Welch and Nuttall published a full report of this case and described the(More)