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BACKGROUND Fatigue has been found to complicate infectious mononucleosis (IM) when patients are directly asked about it. We do not know whether such fatigue is clinically significant, nor whether IM is a specific risk for fatigue (or whether it can follow other common infections). Various risk markers for post-infectious fatigue have been identified, but(More)
BACKGROUND Around 4500 new primary brain tumours are diagnosed in the UK each year. Symptoms of these tumours have not previously been studied in primary care. AIM To identify and quantify the clinical features of brain tumours in primary care. DESIGN OF STUDY Case-control study. SETTING The General Practice Research Database, UK. METHOD A total of(More)
Early diagnosis is a key factor in improving the outcomes of cancer patients. A greater understanding of the pre-diagnostic patient pathways is vital yet, at present, research in this field lacks consistent definitions and methods. As a consequence much early diagnosis research is difficult to interpret. A consensus group was formed with the aim of(More)
The nature of cancer control is changing, with an increasing emphasis, fuelled by public and political demand, on prevention, early diagnosis, and patient experience during and after treatment. At the same time, primary care is increasingly promoted, by governments and health funders worldwide, as the preferred setting for most health care for reasons of(More)
OBJECTIVE To identify and quantify symptoms of ovarian cancer in women in primary care. DESIGN Case-control study, with coding of participants' primary care records for one year before diagnosis. SETTING 39 general practices in Devon, England. PARTICIPANTS 212 women aged over 40 with a diagnosis of primary ovarian cancer, 2000-7; 1060 controls matched(More)
BACKGROUND Fatigue syndromes and irritable bowel syndrome (IBS) often occur together. Explanations include being different manifestations of the same condition and simply sharing some symptoms. METHOD A matched case-control study in UK primary care, using data collected prospectively in the General Practice Research Database (GPRD). The main outcome(More)
BACKGROUND Breast cancer is the most common cancer in the UK. GPs are encouraged to refer all women whose symptoms may represent cancer, rather than selecting those at highest risk. AIM To identify and quantify features of breast cancer in primary care. DESIGN AND SETTING A UK case-control study using the Clinical Practice Research Database (CPRD). (More)
BACKGROUND Although the association between raised platelet count (thrombocytosis) and cancer has been reported in primary and secondary care studies, UK GPs are unaware of it, and it is insufficiently evidenced for laboratories to identify and warn of it. This systematic review aimed to identify and collate evidence from studies that have investigated(More)