William H . Pearce

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BACKGROUND The ankle brachial index (ABI) is a noninvasive, reliable measure of lower-extremity ischemia. However, the relationship between ABI and lower-extremity function has not been well studied. OBJECTIVE To describe the association between the ABI and lower-extremity function. DESIGN Cross-sectional study. SETTING 3 academic medical centers in(More)
PURPOSE Plaque rupture is often the precipitating event in acute coronary syndromes. We hypothesized that a similar process occurs in stenotic carotid plaques in association with ischemic neurologic symptoms. Our purpose was to examine several morphologic features of stenotic carotid plaques and to determine which characteristics are more commonly(More)
BACKGROUND The primary purpose of this study was to evaluate compliance, side effects, and safety associated with prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms (AAAs). A secondary goal was to determine how treatment with doxycycline influences circulating levels of matrix metalloproteinase-9 (MMP-9)(More)
BACKGROUND Visceral artery aneurysms are an uncommon but important form of abdominal vascular disease. This study reviews a contemporary experience with special emphasis on newer methods of diagnosis and treatment. METHODS From 1980 to 1994, 37 patients were diagnosed with 46 visceral artery aneurysms. These consisted of 22 splenic, 10 hepatic, 4 superior(More)
CONTEXT Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC). OBJECTIVE To identify clinical characteristics and functional limitations associated with a broad range of leg symptoms identified among patients with PAD. DESIGN, SETTING, AND PARTICIPANTS(More)
OBJECTIVES Among persons with lower extremity peripheral artery disease (PAD), we determined whether objective measures of walking performance predict mortality independently of the ankle brachial index (ABI). BACKGROUND The ability of office-based functional performance measures to predict mortality in patients with PAD is unknown. METHODS Participants(More)
BACKGROUND A surgical risk model is used to analyze postoperative mortality and late survival for older veterans who underwent above- or below-knee amputations in 119 Veterans Affairs (VA) hospitals from 1991 to 1995. METHODS Preoperative medical conditions and laboratory values abstracted by the VA National Surgical Quality Improvement Program were(More)
BACKGROUND We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease. METHODS AND RESULTS Participants included 392 men and women with an ankle brachial index (ABI) <0.90 and 249 with ABI 0.90 to(More)
OBJECTIVE Percutaneous treatment of an abdominal aortic aneurysm (AAA) is feasible, but is associated with a unique set of risks. A comparison of Excluder endograft deployment with femoral artery cutdown (FAC) versus percutaneous femoral access (PFA) for treatment of infrarenal AAA was undertaken. METHODS A single-institution, controlled, retrospective(More)
Anomalies of the left renal vein (retroaortic left renal vein and left renal vein collar) and the inferior vena cava (left-sided inferior vena cava and caval duplication) occur relatively infrequently but pose potential hazards to the surgeon during aortic repair. We report the cases of three patients in which one or a combination of these anomalies of the(More)