William H. Pearce

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BACKGROUND We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease. METHODS AND RESULTS Participants included 392 men and women with an ankle brachial index (ABI) <0.90 and 249 with ABI 0.90 to(More)
BACKGROUND We determined whether higher levels of D-dimer, C-reactive protein (CRP), fibrinogen, and serum amyloid A are associated independently with functional impairment in patients with and without peripheral arterial disease (PAD). METHODS AND RESULTS Participants were 370 men and women with PAD (ankle brachial index <0.90) and 231 without PAD.(More)
BACKGROUND This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD). METHODS AND RESULTS PAD participants (n=465) had an ankle brachial index <0.90. Non-PAD participants (n=292) had an ankle brachial index of 0.90 to 1.30. PAD(More)
T he Atherosclerotic Peripheral Vascular Disease Interdis-ciplinary Working Group was commissioned by the American Heart Association (AHA) to provide a forum to address important and emerging issues in this multidisciplinary area of clinical science. The working group was a primary outgrowth of the AHA Atherosclerotic Vascular Disease Conference held in(More)
A bdominal aortic aneurysms (AAAs) are the result of a progressive degenerative process characterized by elas-tin depletion and inflammatory changes of the aortic wall. The process leads to gradual enlargement and a localized weakening of the aorta, with eventual rupture. Risk factors include age, sex, family history, and smoking. 1 The normal aortic(More)
INTRODUCTION Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS Monocytes were obtained from 20 patients with SLE and 16(More)
HYPOTHESIS Population-based hospital data indicate that African American patients undergo major lower extremity (LE) amputation 2 to 3 times more frequently than white patients. Some have attributed this to a lack of access to LE revascularization procedures by African American patients. To determine the likelihood that racial disparities in amputation(More)
Background—We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease. Methods and Results—Participants included 392 men and women with an ankle brachial index (ABI) Ͻ0.90 and 249 with ABI 0.90 to(More)
OBJECTIVE To evaluate telomere length (TL) between patients with SLE and healthy controls and to test if TL is associated with carotid plaque. METHODS A pilot study of 154 patients with SLE and 152 controls was performed from the SOLVABLE (Study of Lupus Vascular and Bone Long-Term Endpoints) cohort. Demographic and cardiovascular disease (CVD) factors(More)