William Greentree

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Terfenadine is an antihistamine that has been reported to be safe for use in human beings and animals. This report focuses on an index case of terfenadine toxicosis and several cases of terfenadine toxicosis reported to the National Animal Poison Control Center from 1987 through 1992. Adverse effects of terfenadine can be seen with dosages as low as 6.6(More)
Several recent studies with the sorbitol dehydrogenase inhibitors 4-[4-(N,N-dimethylsulfamoyl)-piperazino]-2-methylpyrimidine, SDH-1, and its active metabolite 4-[4-(N, N-dimethylsulfamoyl)piperazino]-2-hydroxymethylpyrimidine , SDH-2, suggest that inhibition of sorbitol dehydrogenase may be beneficial in delaying the onset of diabetic complications due to(More)
PURPOSE Feeding dogs a diet containing 30% galactose induces experimental galactosemia and results in the formation of diabetes-like microvascular lesions of the retina. The appearance and progression of these retinal lesions can be arrested in a dose-dependent manner by treating these dogs with aldose reductase inhibitors from the onset of galactosemia. To(More)
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