William G. Tharp
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Obesity and asthma: an inflammatory disease of adipose tissue not the airway.
- O. Sideleva, B. Suratt, +6 authors A. Dixon
- American journal of respiratory and critical care…
- 14 December 2012
RATIONALE Obesity is a major risk factor for asthma; the reasons for this are poorly understood, although it is thought that inflammatory changes in adipose tissue in obesity could contribute to… Expand
Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo.
- William G. Tharp, R. Yadav, +11 authors M. Poznansky
- Medicine, Biology
- Journal of leukocyte biology
- 1 March 2006
We report for the first time that primary human neutrophils can undergo persistent, directionally biased movement away from a chemokine in vitro and in vivo, termed chemorepulsion or fugetaxis.… Expand
Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients.
- D. Irimia, Su-yang Liu, William G. Tharp, A. Samadani, M. Toner, M. Poznansky
- Chemistry, Medicine
- Lab on a chip
- 31 January 2006
Experimental systems that provide temporal and spatial control of chemical gradients are required for probing into the complex mechanisms of eukaryotic cell chemotaxis. However, no current technique… Expand
Amyloid precursor protein expression is upregulated in adipocytes in obesity.
The aim of this study was to determine whether amyloid precursor protein (APP) is expressed in human adipose tissue, dysregulated in obesity, and related to insulin resistance and inflammation. APP… Expand
Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes.
- D. D’Alessio, Amanda M Denney, +8 authors R. Pratley
- The Journal of clinical endocrinology and…
CONTEXT Dipeptidyl peptidase 4 (DPP-4) inhibitors are proposed to lower blood glucose in type 2 diabetes mellitus (T2DM) by prolonging the activity of the circulating incretins, glucose-dependent… Expand
Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes
Objective Cardiac natriuretic peptides (NPs) bind to two receptors (NPRA‐mediator of signaling; NPRC‐clearance receptor) whose ratio, NPRR (NPRA/NPRC), determines the NP bioactivity. This study… Expand
Migration ofAntigen-Specific T Cells Away from CXCR4-Binding Human ImmunodeficiencyVirus Type 1gp120
- D. Brainard, William G. Tharp, +8 authors M. Poznansky
- Medicine, Biology
- Journal of Virology
- 15 May 2004
ABSTRACT Cell-mediated immunity depends in part on appropriate migration and localization of cytotoxic T lymphocytes (CTL), a process regulated by chemokines and adhesion molecules. Many viruses,… Expand
Plasma Amyloid-β Peptide Levels Correlate with Adipocyte Amyloid Precursor Protein Gene Expression in Obese Individuals
- Y. Lee, J. Martin, R. Maple, William G. Tharp, R. Pratley
- Medicine, Biology
- 12 August 2009
Background/Aims: Several studies have demonstrated that midlife obesity increases the risk for dementia and Alzheimer’s disease. Moreover, plasma 42-amino-acid amyloid-β (Aβ42) levels appear to… Expand
Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice.
Circulating levels of matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitor of metalloproteinases (TIMPs), are altered in human obesity and may contribute to its… Expand
Long-term Survival of Transplanted Allogeneic Cells Engineered to Express a T Cell Chemorepellent
Background. Alloantigen specific T cells have been shown to be required for allograft rejection. The chemokine, stromal cell derived factor-1 (SDF-1) at high concentration, has been shown to act as a… Expand