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  • Serge H. Boyer, Hongjian Jiang, +11 authors Mark D. Erion
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2008 (First Publication: 27 November 2008)
  • Phosphonic acid (PA) thyroid hormone receptor (TR) agonists were synthesized to exploit the poor distribution of PA-based drugs to extrahepatic tissues and thereby to improve the therapeutic index.Expand
  • Qun Dang, Srinivas Rao Kasibhatla, +10 authors Mark D. Erion
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2008 (First Publication: 1 July 2008)
  • Like most phosphonic acids, the recently discovered potent and selective thiazole phosphonic acid inhibitors of fructose 1,6-bisphosphatase (FBPase) exhibited low oral bioavailability (OBAV) andExpand
  • William G. Schulz, Edward B. Skibo
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2000 (First Publication: 1 February 2000)
  • Described herein are the synthesis, cytotoxic properties, and topoisomerase II inhibition assays of benzodiimidazole and dipyrroloimidazobenzimidazole structural variants of the pyrrolo[1,Expand
  • Edward B. Skibo, Imadul Islam, Matthew J. Heileman, William G. Schulz
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1994
  • The synthesis and cytotoxic properties of benzimidazole-based DNA-cleaving agents are presented herein. These agents include pyrrolo[1,2-a]benzimidazole (PBI), benzimidazole (BI), andExpand
  • William G. Schulz, Ronald A. Nieman, Edward B. Skibo
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1995 (First Publication: 5 December 1995)
  • This report presents evidence that a reduced pyrrolo[1,2-a]benzimidazole (PBI) cleaves DNA as a result of phosphate alkylation followed by hydrolysis of the resulting phosphate triester. TheExpand