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  • Deepak R Thakker, Marcy R Weatherspoon, +5 authors Lisa L Shafer
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 2009 (First Publication: 17 March 2009)
  • Although immunization against amyloid-β (Aβ) holds promise as a disease-modifying therapy for Alzheimer disease (AD), it is associated with an undesirable accumulation of amyloid in theExpand
  • Maria Stella Lombardi, Leonie Jaspers, Christine Spronkmans, Cinzia Gellera, William F. Kaemmerer
  • Biology, Medicine
  • Experimental Neurology
  • 2009 (First Publication: 1 June 2009)
  • Use of RNA interference to reduce huntingtin protein (htt) expression in affected brain regions may provide an effective treatment for Huntington disease (HD), but it remains uncertain whetherExpand
  • Dao Pan, R. Gunther, +5 authors C. Whitley
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 2002 (First Publication: 1 July 2002)
  • Lentiviral vectors can confer high levels of gene transfer and transgene expression in a variety of cell types. However, the biodistribution and toxicity after intravenous administration have notExpand
  • P. H. J. van Bilsen, L. Jaspers, M. Lombardi, J. C. Odekerken, E. Burright, W. Kaemmerer
  • Biology, Medicine
  • Human gene therapy
  • 2008 (First Publication: 17 July 2008)
  • Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by the expression of mutant huntingtin protein (Htt). Suppression of Htt expression, using RNA interference,Expand
  • William F. Kaemmerer, Cecília M. P. Rodrigues, Clifford J. Steer, Walter C. Low
  • Biology, Medicine
  • Neuroscience
  • 2001 (First Publication: 1 March 2001)
  • It is not known why expression of a protein with an expanded polyglutamine region is pathogenic in spinocerebellar ataxia, Huntington's disease and several other neurodegenerative diseases. DietaryExpand