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- Lars L. Gustafsson, William F. Ebling, Eiji Osaki, Donald R. Stanski
- Anesthesiology
- 1996
BACKGROUND
In contrast to that of inhalational anesthetics, quantitation of anesthetic depth for intravenous agents has not been well defined. In this study, using rodents, the relationship between… (More)
- Ashu Sharma, William F. Ebling, William J. Jusko
- Journal of pharmaceutical sciences
- 1998
A precursor-dependent model of indirect pharmacodynamic response which can describe tolerance and rebound was characterized in terms of the effects of changes in the fundamental properties of the… (More)
- William F. Ebling, D. Russell Wada, Donald R. Stanski
- Journal of Pharmacokinetics and Biopharmaceutics
- 1994
Physiologically based pharmacokinetic modeling procedures employ anatomical tissue weight, blood flow, and steady tissue/blood partition data, often obtained from different sources, to construct a… (More)
- Suvendra N. Dutta, Yukihiro Matsumoto, William F. Ebling
- Journal of pharmaceutical sciences
- 1997
- D. Russell Wada, Sven Björkman, William F. Ebling, Hideyoshi Harashima, Sandra R. Harapat, Donald R. Stanski
- Anesthesiology
- 1997
BACKGROUND
Understanding the influence of physiological variables on thiopental pharmacokinetics would enhance the scientific basis for the clinical usage of this anesthetic.
METHODS
A… (More)
- William J. Jusko, Hui C. Ko, William F. Ebling
- Journal of Pharmacokinetics and Biopharmaceutics
- 1995
The article by Verotta and Sheiner (1) provides a cogent extension of the indirect response models (IRM) of Dayneka et al. (2) to accommodate a linear "effect compartment" as a biophase for the drug… (More)
- Suvendra N. Dutta, Yukihiro Matsumoto, N U Gothgen, William F. Ebling
- Journal of pharmaceutical sciences
- 1997
Propofol is a unique highly lipid-soluble anesthetic that is formulated in a fat emulsion (Diprivan) for intravenous (i.v.) use. It has the desirable properties of rapid onset and offset of effect… (More)
- William F. Ebling, William J. Jusko
- Journal of Pharmacokinetics and Biopharmaceutics
- 1986
Methods based on moment analysis are described which permit the calculation of the fundamental parameters of reversible drug/metabolite systems. These parameters include the four essential clearances… (More)
- Sven Björkman, Donald R. Stanski, +4 authors William F. Ebling
- Journal of Pharmacokinetics and Biopharmaceutics
- 1993
Traditionally, physiological pharmacokinetic models assume that arterial blood flow to tissue is the rate-limiting step in the transfer of drug into tissue parenchyma. When this assumption is made… (More)
- Craig Laforce, Stanley J Szefler, Mark F. Miller, William F. Ebling, Mathew Brenner
- The Journal of allergy and clinical immunology
- 1983
Methylprednisolone elimination is reduced in the presence of treatment with troleandomycin (TAO), a macrolide antibiotic. To assess whether a similar interaction occurs with a more commonly used and… (More)