William F Bennett

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B2036-PEG, a GH receptor (GH-R) antagonist, is an analog of GH that is PEG-modified to prolong its action. Nine mutations alter the binding properties of this molecule, preventing GH-R dimerization and GH action. A potential therapeutic role of B2036-PEG is to block GH action, e.g. in refractory acromegaly. A phase I, placebo-controlled, single rising-dose(More)
OBJECT The authors have previously demonstrated that modulation of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis can significantly affect meningioma growth in vitro. These studies were performed to evaluate the efficacy of GH receptor blockade in vivo. METHODS Primary cultures from 15 meningioma tumors obtained in humans were(More)
A 48-year-old man presented with the numb, clumsy hand syndrome. Evaluation revealed a high cervical cord lesion. Surgical exploration discovered leptomeningeal gliomatosis with no discernible intraparenchymal component. The clinical features of the case, the neuroimaging studies including magnetic resonance scanning, and the most unusual pathological(More)
BACKGROUND Superior labral anterior to posterior (SLAP) lesions have been well described in the literature and are thought to be secondary to traction injuries to the biceps anchor and/or falls on the outstretched arm. The pulley has recently been described as a structure that aids in the prevention of biceps instability. The intra-articular subscapularis(More)
Lateral knee portal placement is defined by and divided into five anatomic zones (A through E) beginning just anterolateral to the patellar ligament and proceeding posteriorly at 1-cm intervals. The arthroscopic anatomy and the open dissected lateral knee anatomy are correlated in this study with a fresh frozen cadaver. Zone A includes the anterolateral(More)
A characteristic pattern of altered lumbar spine endplate morphology has been frequently noted in patients being evaluated for unrelated indications. The "owl's eyes" configuration of intravertebral disc material on axial transverse computed tomographic sections easily distinguishes this normal variant from pathologic processes. Two representative cases are(More)
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