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Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Channeling Ebola virus entry into the cell The current outbreak of Ebola virus in West Africa highlights the need for antiviral therapies. One strategy would be to block the Ebola virus's ability toExpand
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Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody–drug conjugates
PurposeTargeting tubulin binders to cancer cells using antibody–drug conjugates (ADCs) has great potential to become an effective cancer treatment with low normal tissue toxicity. The nature of theExpand
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Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.
The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation ofExpand
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A New Process for Antineoplastic Agent Clofarabine
Clofarabine is a promising DNA polymerase inhibitor currently in clinical trials for a variety of liquid and solid tumor indications. The efforts for development of a new manufacturing process forExpand
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Taxane diterpenes 1. Control of relative and absolute stereochemistry in intramolecular pyrylium ylide-alkene cyclizations for the synthesis of taxol precursors
Intramolecular pyrylium ylide-alkene cyclizations provide control of the absolute stereochemistry at the crucial C-19 angular methyl group, and leads to bicyclo[5.4.03,8]undecenones that contain theExpand
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Formal synthesis of angiogenesis inhibitor NM-3.
We report the formal synthesis of angiogenesis inhibitor NM-3 (1) in six steps from either of the 2,4-dimethoxyhalobenzenes 13a,b or 3,5-dimethoxychlorobenzene (13c). The first key reaction is theExpand
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Chromium and tungsten pentacarbonyl groups as reactivity auxiliaries in the Diels-Alder reactions of alkenyl carbene complexes with 1,3-dienes
Reactions de complexe du type R 1 CH=CHC(OMe)=M(CO) 3 (R 1 =H,CH 3 (trans), M=Cr, Mo, W) avec l'isoprene et des complexes du type R 1 R 2 C=CR 3 (OMe)=M(CO) 5 (R 1 ,R 2 ,R 3 =H; R 1 =CH 3 , R 2 R 3Expand
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Synthetic and mechanistic studies on the antitumor antibiotics esperamicin A1 and calicheamicin .gamma.1: synthesis of 2-ketobicyclo[7.3.1.]enediyne and 13-ketocyclo[7.3.1]enediyne cores mediated by
A general strategy for the construction of the bicyclo[7.3.1]tridecenediyne core structure of the antitumor antibiotics esperamicin and calicheamicin can be realized provided the 10,11-acetylenicExpand
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Development of an Improved Process for Doxercalciferol via a Continuous Photochemical Reaction
Doxercalciferol (1α-hydroxyvitamin D2) is a commercially approved vitamin D derivative used to treat chronic kidney disease (CKD) patients whose kidneys cannot metabolically introduce a hydroxylExpand
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