William E. Bauta

Publications
Influence

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

Y. Sakurai, A. Kolokoltsov, +7 authors R. Davey
Biology, Medicine
Science
27 February 2015

Channeling Ebola virus entry into the cell The current outbreak of Ebola virus in West Africa highlights the need for antiviral therapies. One strategy would be to block the Ebola virus's ability to… Expand

A regioselective entry to vinyllithiums from unsymmetrical ketones via enol triflates

W. Wulff, G. A. Peterson, +6 authors Christopher K. Murray
Chemistry
1986

Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody–drug conjugates

Diego A. Gianolio, C. Rouleau, +13 authors B. Teicher
Chemistry, Medicine
Cancer Chemotherapy and Pharmacology
22 July 2012

PurposeTargeting tubulin binders to cancer cells using antibody–drug conjugates (ADCs) has great potential to become an effective cancer treatment with low normal tissue toxicity. The nature of the… Expand

Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.

Stanton F McHardy, Jonathan Bohmann, +13 authors J. Mcdonough
Chemistry, Medicine
Bioorganic & medicinal chemistry letters
1 April 2014

The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of… Expand

A New Process for Antineoplastic Agent Clofarabine

William E. Bauta, Brian E. Schulmeier, +7 authors R. Guo
Chemistry
24 September 2004

Clofarabine is a promising DNA polymerase inhibitor currently in clinical trials for a variety of liquid and solid tumor indications. The efforts for development of a new manufacturing process for… Expand

Taxane diterpenes 1. Control of relative and absolute stereochemistry in intramolecular pyrylium ylide-alkene cyclizations for the synthesis of taxol precursors

William E. Bauta, J. A. Booth, +11 authors F. Ujjainwalla
Chemistry
4 November 1996

Intramolecular pyrylium ylide-alkene cyclizations provide control of the absolute stereochemistry at the crucial C-19 angular methyl group, and leads to bicyclo[5.4.03,8]undecenones that contain the… Expand

Formal synthesis of angiogenesis inhibitor NM-3.

William E. Bauta, D. Lovett, W. Cantrell, Brian Burke
Chemistry, Medicine
The Journal of organic chemistry
20 June 2003

We report the formal synthesis of angiogenesis inhibitor NM-3 (1) in six steps from either of the 2,4-dimethoxyhalobenzenes 13a,b or 3,5-dimethoxychlorobenzene (13c). The first key reaction is the… Expand

Chromium and tungsten pentacarbonyl groups as reactivity auxiliaries in the Diels-Alder reactions of alkenyl carbene complexes with 1,3-dienes

W. Wulff, William E. Bauta, +4 authors D. Yang
Chemistry
1 April 1990

Reactions de complexe du type R 1 CH=CHC(OMe)=M(CO) 3 (R 1 =H,CH 3 (trans), M=Cr, Mo, W) avec l'isoprene et des complexes du type R 1 R 2 C=CR 3 (OMe)=M(CO) 5 (R 1 ,R 2 ,R 3 =H; R 1 =CH 3 , R 2 R 3… Expand

Synthetic and mechanistic studies on the antitumor antibiotics esperamicin A1 and calicheamicin .gamma.1: synthesis of 2-ketobicyclo[7.3.1.]enediyne and 13-ketocyclo[7.3.1]enediyne cores mediated by…

P. Magnus, P. Carter, +5 authors Simon M. Fortt
Chemistry
1 March 1992

A general strategy for the construction of the bicyclo[7.3.1]tridecenediyne core structure of the antitumor antibiotics esperamicin and calicheamicin can be realized provided the 10,11-acetylenic… Expand

Development of an Improved Process for Doxercalciferol via a Continuous Photochemical Reaction

B. G. Anderson, William E. Bauta, W. Cantrell
Chemistry
22 February 2012

Doxercalciferol (1α-hydroxyvitamin D2) is a commercially approved vitamin D derivative used to treat chronic kidney disease (CKD) patients whose kidneys cannot metabolically introduce a hydroxyl… Expand

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