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We describe a methodology that enables the real-time diagnosis of performance problems in complex high-performance distributed systems. The methodology includes tools for generating precision event logs that can be used to provide detailed end-to-end application and system level monitoring; a Java agent-based system for managing the large amount of logging… (More)
As the practice of science moves beyond the single investigator due to the complexity of the problems that now dominate science, large collaborative and multi-institutional teams are needed to address these problems. In order to support this shift in science, the computing and data handling infrastructure that is essential to most of modern science must… (More)
Muscarinic and NMDA receptors contribute to post-traumatic hypersensitivity to secondary ischemia. However, the effect of these receptor antagonists on behavior and CA1 neuronal death after traumatic brain injury (TBI) with acute (1 h after TBI) forebrain ischemia has not been systematically assessed. We examined cognitive and motor dysfunction and the… (More)
We have designed, built, and analyzed a distributed parallel storage system that will supply image streams fast enough to permit multi-user, “real-time”, video-like applications in a wide-area ATM network-based Internet environment. We have based the implementation on user-level code in order to secure portability; we have characterized the… (More)
We have observed many focal dilatations or very small aneurysms in terminal arterioles and capillaries of 4 of 5 patients and 6 dogs who had recently undergone cardiopulmonary bypass. A smaller number of sausagelike dilatations distended medium-sized arterioles. Two other patients had a small number of the same microvascular changes following proximal… (More)