William E. Frawley

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William Frawley's original and wide-ranging new book embraces linguistics, artificial intelligence, philosophy, and psychology in seeking a reconciliation between contemporary cognitive science and Vygotskian psychology. Lev Semenovich Vygotsky (1896--1934) was a Russian psychologist who founded the sociocultural school of psychology, which is based upon(More)
BACKGROUND There is a poor correlation between multiple sclerosis disease activity, as measured by magnetic resonance imaging, and clinical disability. OBJECTIVE To establish oculographic criteria for the diagnosis and severity of internuclear ophthalmoparesis (INO), so that future studies can link the severity of ocular dysconjugacy with(More)
The purpose of this study was to determine the sensitivity of discourse gist measures to the early cognitive-linguistic changes in Alzheimer disease (AD) and in the preclinical stages. Differences in discourse abilities were examined in 25 cognitively normal adults, 24 adults with mild probable AD, and 20 adults with mild cognitive impairment (MCI) at gist(More)
BACKGROUND Thalamic deep brain stimulation ameliorates essential and parkinsonian tremors refractory to medications. Stimulus voltage, polarity configuration, frequency, and pulsewidth can each be adjusted in order to optimize tremor control and maximize battery life. The relative impacts of these programmable variables have not previously been quantified.(More)
Previous research indicates that perceived orientation and/or alignment of segments and points can vary as a function of the angular position of the stimulus elements. Several studies show that the variability of the responses is least and accuracy of judgment is greatest where segments and dots are aligned with a cardinal axis. Additionally, some report(More)
In prior work from this laboratory, we have examined how accurately subjects can judge collinearity, i.e. alignment, as a function of the angular position of stimulus elements. In those experiments, subjects were presented with a line segment (or a pair of dots) which varied across the 360 degrees range of angular positions, and were required to select and(More)
It is well known that judgments of oblique line segments are more variable and less accurate than are judgments of horizontal or vertical segments, i.e., the "oblique effect." A prior study from our laboratories confirmed these differentials for a task in which the collinearity of segments at various angular positions was judged. Further, that study found(More)
Myeloperoxidase (MPO) is a major enzyme found in neutrophils. Oxidation by MPO produces free radicals that demonstrate genotoxic properties. A polymorphism (G to A) within the promotor region of the MPO gene reduces transcription and expression. This polymorphism is associated with a protective effect against some cancers in adults including lung cancer.(More)
This paper is a response to commentaries on my target paper for Computational Intelligence, “Control and Cross-Domain Mental Computation: Evidence from Language Breakdown.” In this response, I acknowledge certain errors in my initial construal of control and dismiss unwarranted criticisms. I then reexamine both control and certain language disorders in(More)
Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects. Mice fed DHEA (0.45% w/w of food) and mice pair-fed to these mice (food restricted) for 8 weeks were tested for changes in(More)