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Diabetes in Chinese hamster was initially detected by qualitative tests for urine glucose. The disease was characterized by quantitating urine glucose, glucose tolerance tests and measurement of fasting and nonfasting blood sugar, blood ketones, plasma free fatty acids (FFA), plasma insulin, pancreatic insulin and fasting levels of liver glycogen. In(More)
Distal tibial nerves of 14 chronically diabetic and 6 control Chinese hamsters were examined using ultrastructural and teased whole-mount methods. Glucosuria was present for varying intervals up to 976 days, while 10 hamsters manifested ketonuria for intervals up to 551 days. Myelin internodal ensheathment patterns were analyzed from whole-mount(More)
Islets of Langerhans of 15 Chinese hamsters (7 diabetic and 8 either related or unrelated controls of the same sex and age) have been examined by electron microscopy. Beta cells of control animals predominate and have abundant granules most of which are vesicles of varying sizes with a pale granular or homogeneous content. Only a few have a dense central(More)
Three groups of Chinese hamsters bred at the Upjohn Laboratory were studied: these included diabetic animals in which symptoms were present for 18 months, non-diabetic siblings and non-related, non-diabetic animals of the corresponding age and sex. The spontaneous diabetes is characterized by hyperglycemia, glycosuria, decreased islet volume, decreased beta(More)
The mutant mouse, C 57 BL/KsJ -db, develops spontaneous diabetes with many symptoms similar to those observed in the diabetic human. Food intake, body weight, and plasma insulin in thedb mouse were increased by 4 weeks of age and blood sugar by 7 weeks. The blood sugar continued to increase with age but by 3 months plasma insulin, pancreatic insulin, and(More)
Intracellular glycogen deposits were consistently found in the retina, kidney and pancreatic islets of diabetic-ketonuric Chinese hamsters. Accumulation of glycogen in the outer nuclear layer of the retina was mostly associated with severity of the disease, but was not related to age or sex. The type of retinal cell involved in the accumulation of glycogen(More)