William Donovan

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The charts of twenty-four patients from whom Mycobacterium simiae was isolated from the sputum were reviewed and the patients seen in follow-up examination when possible. They were divided into 3 groups: 2 patients were felt to have had definite infection with M. simiae, 3 were felt to have had probable infection, and 19 showed no evidence of infection(More)
Ketoconazole was given to 18 patients with coccidioidomycosis. Fourteen had received prior antifungal chemotherapy with amphotericin B, miconazole, or both. Ten patients had pulmonary disease, two had meningitis, and six had extrameningeal disseminated disease. The initial dose of ketoconazole was 200 mg per day; it was later increased to 400 mg per day for(More)
Although more informative and precise diagnostic methods have become available, cytologic analysis of sputum is still considered the first step in evaluating bronchogenic carcinoma. We hypothesized that the cost of sputum examinations far outweighed their usefulness in actual patient management. To substantiate this, we retrospectively reviewed the charts(More)
We treated 29 patients with ketoconazole for systemic mycoses. Twenty-two had coccidioidomycosis, 5 had histoplasmosis, and 2 had sporotrichosis. Of the 25 patients who received 200 mg/day, 16% improved on that dose. Of 17 patients who did not improve on 200 mg/day, 71% responded after the dose was increased to 400 or 800 mg/day. Treatment periods ranged(More)
The occurrence of pressure sores is a major obstacle to the long-term rehabilitation of the spinal cord--injured patient. To achieve the best functional result with the most efficient use of resources, a comprehensive treatment plan is needed. In our twenty-five-year experience we have evolved guidelines for the perioperative management of the spinal(More)