William David Nes

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This article reviews the design and study, in our own laboratory and others, of new steroidal triterpenes with a modified lanosterol or cycloartenol frame. These compounds, along with a number of known analogs with the cholestane skeleton, have been evaluated as reversible or irreversible inhibitors of sterol C24-methyltransferase (SMT) from plants, fungi(More)
his award address was " Using Sterols to Probe the Structure and Define the Function of Membrane Organization. " Dr. London conducted pioneer research on the identification of " lipid rafts " in biological membranes [3]. Dr. London graciously agreed to provide the review which is the first paper in this volume. The review is followed by four additional(More)
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