William D. Parker

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R. G. Hennig,1,2,* A. Wadehra,2 K. P. Driver,2 W. D. Parker,2 C. J. Umrigar,3 and J. W. Wilkins2 1Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853-1501, USA 2Department of Physics, The Ohio State University, Columbus, Ohio 43210, USA 3Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New(More)
The thalamic relay neurons, reticular thalamic nucleus, and neocortical pyramidal cells form a circuit that sustains oscillatory burst firing, and is regarded as the underlying mechanism of absence seizures. T-type calcium channels play a key role in this circuit. Here, we review the role of T-type calcium channel genes in the development of absence(More)
Accumulations of mitochondrial DNA (mtDNA) mutations associated with aging are evident in multiple human tissues. The role of mtDNA mutations can be observed in an aging animal model such as homozygous knock-in PolgA mice, which have a large colonial expansion of mtDNA mutations. They develop reduced lifespan and premature onset of age-related phenotypes,(More)
BACKGROUND Mitochondrial dysfunction may play a central role in the pathologic process of Alzheimer's disease (AD), but there is still a scarcity of data that directly links the pathology of AD with the alteration of mitochondrial DNA. This study aimed to provide a comprehensive assessment of mtDNA rearrangement events in AD brain tissue. PATIENTS AND(More)
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