William D. Heavlin

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Spinal muscular atrophy (SMA) is a motor neuron disease caused by dysfunction of the survival motor neuron (SMN) gene. Human SMN gene is present in duplicated copies: SMN1 and SMN2. More than 95% of patients with SMA lack a functional SMN1 but retain at least one copy of SMN2. Unlike SMN1, SMN2 is primarily transcribed into truncated messenger RNA and(More)
When wholesale prices are high and/or when the electricity system reliability is jeopardized, utilities have programs that encourage their customers to shed loads; these programs are called demand response (DR). Most large energy consumers, for example the buildings comprising Google's Mountain View, CA campus, have some ability to control, and therefore(More)
Conventional factory productivity measures discount experiments as inefficient. Motivated by the research and development environment of semiconductor manufacturing, this work proposes a complementary factory metric, potential information. The proposal adapts and modifies somewhat the D-optimal criterion of experimental design theory. Desirable properties(More)
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