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1. Whole-cell voltage-clamp recordings in an in vitro brainstem-cranial nerve explant preparation were used to assess the local circuitry activated by vagal input to nucleus tractus solitarii (NTS) neurones in immature rats. 2. All neurones that responded to vagal stimulation displayed EPSCs of relatively constant latency. Approximately 50 % of these also(More)
Single-unit activity that responded to phasic gastric distension was recorded extracellularly from neurons in brain stem of anesthetized cats during local substance P chemically induced changes in wall tension. Local gastric intra-arterial administration of substance P via splenic artery often produced a triphasic gastric response. Gastric changes were(More)
Gastric vagally evoked extracellular unitary responses were recorded in the hypothalamus of anesthetized cats. The evoked unitary responses were localized in the paraventricular dorsomedial region, ventromedial nucleus, and lateral hypothalamus. The mean latency of the gastric vagally evoked hypothalamic neuronal responses in these three areas ranged from(More)
An in vitro neonatal rat preparation, consisting of the isolated caudal brainstem and stomach joined by the intact vagi, was developed using Sprague-Dawley rats. The animals were 0 to 4 days of age. This preparation provided an opportunity to investigate the extracellular and intracellular responses of neurons in the nucleus tractus solitarius (NTS) of the(More)
A growing literature documents the relationship between tongue strength and oral phase swallowing function. Objective measures of strength have been recommended as more valid and reliable than subjective measures for the assessment of tongue function, yet subjective measures remain the more commonly used clinical method for assessing tongue strength. This(More)
Brainstem unitary responses to gastric vagal-splanchnic nerve interactions were evaluated in anesthetized cats during electrical stimulation of the nerves. The gastric branches of the dorsal and ventral vagal trunks which serve the proximal stomach were electrically stimulated while recording in nucleus solitarius in the brainstem to identify evoked unitary(More)
Unitary responses to electrical stimulation of gastric vagal fibers, that serve the proximal stomach and join the dorsal vagal trunk, were bilaterally distributed in nucleus tractus solitarus (NTS) in the brainstem of the cat. The vagally activated brainstem responses consisted of single or multiple spikes with a mean latency of 281 (SD +/- 43 ms) which(More)
To explore the physiological characteristics of central projections of gastric afferent fibers, single-unit activity was recorded extracellularly from neurons in the brain stem during phasic distension of the stomach in cats anesthetized by halothane and nitrous oxide. The brain stem units were identified on the basis of discharge patterns that were phase(More)
The responses of neurons in the area postrema (AP) during electrical stimulation of the gastric vagal branches that serve the proximal stomach were evaluated in halothane-anesthetized cats. The evoked orthodromic responses were localized bilaterally in the AP and had a mean latency of 272 ms (SD +/- 53.1). Convergence of gastric vagal input on single AP(More)
Unitary responses were recorded extracellularly in the parabrachial nucleus (PBN) in anesthetized cats during electrical stimulation of the 1) gastric branches of the ventral and dorsal vagal trunks which serve the proximal stomach, and 2) left greater splanchnic nerve. The gastric vagally evoked parabrachial responses consisted of phasic single and(More)