William Chen

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Angiogenesis is central to many physiological and pathological processes. Here we show two potent bioinformatically-identified peptides, one derived from collagen IV and translationally optimized, and one from a somatotropin domain-containing protein, synergize in angiogenesis and lymphangiogenesis assays including cell adhesion, migration and in vivo(More)
Discovering the mechanisms by which genetic variation influences phenotypes is integral to understanding life-history evolution. Models describing causal relationships among traits in a developmental hierarchy provide a functional basis for understanding the correlations often observed among life-history traits. In this paper, we evaluate a developmental(More)
INTRODUCTION Despite positive preclinical/clinical trials, a major hurdle in the clinical application of bevacizumab, an antiangiogenic therapy, in glioblastoma is the development of resistance and progression following a transient response period. METHODS We established a multigenerational glioblastoma xenograft model of acquired bevacizumab resistance(More)
Double eyelid surgery to create an upper-lid crease in Asian patients is one of the more popular aesthetic surgeries among people of Asian descent. Much has been written about the myriad methods, but little has been written about the underlying factors that predispose a patient to complications and suboptimal results. This article touches on some of the(More)
In contrast to much of the previous literature, we argue that the partisan gender gap—the tendency of men to identify more as Republicans and less as Democrats than women—emerged because long-standing ideological differences between men and women became more relevant to party choices when the parties became more ideologically polarized. We hypothesize that(More)