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Single photon emission computed tomography (SPECT) myocardial 201TI imaging appears to offer major improvements over planar imaging. Quantitative analysis of the 201TI images appears to offer major advantages over subjective analysis in planar imaging, but the three-dimensional data available in SPECT images requires special approaches to analysis and(More)
We have developed a procedure to detect patient motion during a tomographic acquisition. The method uses frame-to-frame cross-correlation functions of the summed profiles in the vertical and horizontal directions of the planar images. The quantitative output derived from examination of the variation of the change in the pixel value, corresponding to the(More)
We study the set of probability distributions visited by a continuous-time quantum walk on graphs. An edge-weighted graph G is universal mixing if the instantaneous or average probability distribution of the quantum walk on G ranges over all probability distributions on the vertices as the weights are varied over non-negative reals. The graph is uniform(More)
Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury. We also found that its deletion in the(More)
This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England.(More)
Adjusted-dose subcutaneous unfractionated heparin (SC heparin) was used in the initial management of deep venous thrombosis (DVT) to allow shortened hospital stay. Of 78 patients screened, 41% were eligible and 18 (23%) were enrolled. Follow-up venous ultrasound examination was performed 6 weeks after discharge. Of enrolled patients, 16 (89%) completed the(More)
BACKGROUND Lipid lowering with statins prevents adverse cardiac events. Both lipid-lowering and antioxidant therapies may favorably affect vasomotor function and thereby improve ischemia. METHODS AND RESULTS In a randomized, double-blind, placebo-controlled trial, 300 patients with stable coronary disease, a positive exercise treadmill test, 48-hour(More)
The exploitation of today's high-performance computer systems requires the effective use of parallelism in many forms and at numerous levels. This survey article discusses program analysis and restructuring techniques that target parallel architectures. We first describe various categories of architectures that are oriented toward parallel computation(More)