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Virtual Screening for R-Groups, including Predicted pIC50 Contributions, within Large Structural Databases, Using Topomer CoMFA

• Richard D. Cramer, Phillip Cruz, +4 authors Farhad Soltanshahi
• Journal of Chemical Information and Modeling
• 2008

Multiple R-groups (monovalent fragments) are implicitly accessible within most of the molecular structures that populate large structural databases. R-group searching would desirably consider pIC50… (More)

Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling.

• Jeffrey Alan Kramer, Sandra W. Curtiss, +6 authors Roderick Todd Bunch
• Chemical research in toxicology
• 2004

Currently, the only way to identify nongenotoxic hepatocarcinogens is through long-term repeat dose studies such as the 2 year rodent carcinogenicity assay. Such assays are both time consuming and… (More)

Secondary structure of Bombyx mori and Dictyostelium discoideum 5S rRNA from S1 nuclease and cobra venom ribonuclease susceptibility, and computer assisted analysis.

• Anthony B. Troutt, Thierry Savin, William C. Curtiss, J. J. Celentano, J. N. Vournakis
• Nucleic acids research
• 1982

The 5S rRNAs from Bombyx mori and Dictyostelium discoideum were end-labeled with [32-P] at either the 5' or 3' end and sequenced using enzymatic digestion. The secondary structure of these molecules… (More)

Quantitation of base substitutions in eukaryotic 5S rRNA: Selection for the maintenance of RNA secondary structure

• William C. Curtiss, J. N. Vournakis
• Journal of Molecular Evolution
• 1984

Eukaryotic 5S rRNA sequences from 34 diverse species were compared by the following method: (1) The sequences were aligned; (2) the positions of substitutions were located by comparison of all… (More)

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