William C. Tang

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A clamp-and-ratchet microstructure based on poly crystalline silicon (polysilicon) microelectromechanical systems (MEMS) technology has been designed to exert mechanical tension along radial glial processes between groups of neural stem cells to study the effect of tension on cerebral cortex neurogenesis. FEA analysis shows that the design should not fail(More)
UNLABELLED In this article we demonstrate the effect of mechanical compression on the behavior of cultured neural stem cells using a microelectromechanical system platform. Polydimethylsiloxane (PDMS)-based stretchable substrates were used on a neurosphere (NS) assay to investigate the role of mechanical forces on the formation of radial glial processes and(More)
—The mechanical interactions between cells and the extracellular matrix (ECM) play important roles in many biological processes, including cell proliferation, migration, and differentiation. The cells can probe the stiffness of the ECM and alter their own function accordingly. The objective of this study was to investigate the applicability of a(More)
A microfluidic platform is designed, fabricated, tested, and demonstrated that the unique surface morphologies of avian red blood cells (aRBCs) infected by the malaria parasite Plasmodium gallinaceum enables the cells to interact with the roughened surface and become immobilized inside the microfluidic channels. It is also found that a roughened glass(More)
Design of microfabricated strain gauge array to monitor bone deformation in vitro and in vivo, " Proc., IEEE 4 th Symp. Abstract We present the design of a strain gauge embedded in polydimethylsiloxane (PDMS) that could be implanted and used for monitoring strain on surfaces of bones with high resolution. Our ultimate goal is to design and fabricate the(More)
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