William C Reid

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Emerging evidence suggests that both human stem cells and mature stromal cells can play an important role in the development and growth of human malignancies. In contrast to these tumor-promoting properties, we observed that in an in vivo model of Kaposi's sarcoma (KS), intravenously (i.v.) injected human mesenchymal stem cells (MSCs) home to sites of(More)
Suppressor of cytokine signaling-1 (SOCS-1) is an induc-ible negative regulator of the JAK/STAT signal pathway; SOCS-1 is expressed in dendritic cells (DCs) and negatively regulates activation and type 1 regulatory cytokine production. Infection with human immunodeficiency virus type 1 (HIV-1) results in cytokine dysregulation by DCs. Since effector/memory(More)
The HIV protease inhibitor ritonavir has activities apparently unrelated to its inhibition of the HIV protease, including anti-tumor activity in vivo and in vitro, induction of lipodystrophy in vivo, proteasome inhibition, and inhibition of NFκ. Here we show that ritonavir inhibits activation of NF-AT induced by PMA plus ionomycin and by the human herpes(More)
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