William B Wince

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RATIONALE After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI is promoted as an excellent method to delineate the AAR. However, the evidence supporting the validity of this method to measure the AAR is indirect, and it has never been(More)
BACKGROUND Thoracic aortic aneurysms (TAAs) develop secondary to abnormal aortic extracellular matrix remodeling, resulting in a weakened and dilated aortic wall that progressed to rupture if left unattended. Currently, no diagnostic/prognostic tests are available for the detection of TAA disease. This is largely driven by the lack of a large animal model,(More)
C linically relevant cardiovascular imaging methods to assess response to therapy and prognosis in patients presenting with acute ST segment elevation myocardial infarction (STEMI) are predicated upon their ability to accurately delineate both the area of myocardial infarction and the area of myocardium at risk for infarction secondary to coronary artery(More)
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