William B. Motherwell

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The hypoxic response in humans is regulated by the hypoxia-inducible transcription factor system; inhibition of hypoxia-inducible factor (HIF) activity has potential for the treatment of cancer. Chetomin, a member of the epidithiodiketopiperazine (ETP) family of natural products, inhibits the interaction between HIF-alpha and the transcriptional coactivator(More)
Kristina M. Cook, Stephen T. Hilton, Jasmin Mecinović, William B. Motherwell , William D. Figg, and Christopher J. Schofield From NCI, National Institutes of Health, Bethesda, Maryland 20814, the Chemistry Research Laboratory, Department of Chemistry, and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford OX1 3TA, United(More)
The first N2 complex stabilised by N-heterocyclic carbene ligands, Fe(C-N-C)(N2)2, has been obtained by the reduction of Fe(C-N-C)Br2 where C-N-C = 2,6-bis(aryl-imidazol-2-ylidene)pyridine, aryl = 2,6-Pr(i)2C6H3, with Na(Hg); it serves as a convenient precursor for other iron NHC 'pincer' complexes of the type Fe(C-N-C)(N2)L where L = C2H4, PMe3 and(More)
A comparative study using NMR spectroscopy and designed top-pan molecular balances demonstrates that the noncovalent interaction of a hydroxy group with π-deficient pyrazine and quinoxaline units involves a lone pair-heteroarene interaction which is much stronger and solvent independent when measured relative to the classical π-facial hydrogen bond to a(More)
A binding site optimisation protocol for the design of artificial enzymes based on "small molecule-small molecule" binding studies by diffusion NMR is presented. Since the reaction chosen was the hydrolysis of ester 1 ([4-(4-carboxy-1-oxobutyl)-aminobenzyl]-phenethyl ester), an analogous phosphonate ester 2 ([4-(4-carboxy-1-oxobutyl)-aminobenzyl]-phosphonic(More)
The D-isomer of the naturally-occurring tripeptide glutathione (gamma-L-Glu-L-Cys-Gly, L-GSH) has been synthesised using the Fmoc solid phase peptide synthesis strategy. The D-GSH obtained has been nitrosated to give the D-isomer of the bioactive thionitrite, S-nitroso-L-glutathione. The biological activity of both enantiomers of S-nitrosoglutathione has(More)
A comparative study of molecular balances by NMR spectroscopy indicates that noncovalent functional-group interactions with an arene dominate over those with an alkene, and that a π-facial intramolecular hydrogen bond from a hydroxy group to an arene is favored by approximately 1.2 kJ mol(-1). The strongest interaction observed in this study was with the(More)