William B. L. Wong

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The use of pharmacogenetic testing in clinical practice is limited thus far. A potential barrier to the widespread implementation of pharmacogenetic testing is the lack of evidence on whether testing provides good value for money. The objective of this review was to provide a systematic and critical review of economic evaluations of pharmacogenetic testing.(More)
1 A shorter version of this paper appeared in the Proceedings of the Metrics’98 Symposium, IEEE CS Press Abstract This paper describes ongoing research directed at formulating a set of appropriate measures for assessing and ultimately predicting effort requirements for multimedia systems development. Whilst significant advances have been made in the(More)
BACKGROUND Studies demonstrate the potential for statins to prevent dementia and Alzheimer's disease (AD), but the evidence is inconclusive. OBJECTIVE Conduct a meta-analysis to estimate any benefit of statins in preventing dementia and examine the potential effect of study design and confounding on the benefit of statins in dementia. A secondary goal is(More)
OBJECTIVE The objective of this study was to assess the value of research of the RxPONDER study, an ongoing comparative effectiveness RCT designed to evaluate a 21-gene profile in early stage, node-positive breast cancer. METHODS We developed a disease-based decision-analytic model to compare use of the 21-gene profile versus standard care. Key clinical(More)
The development of multimedia information systems must be managed and controlled just as it is for other generic system types. This paper proposes an approach for assessing multimedia component and system characteristics with a view to ultimately using these features to estimate the associated development effort. Given the different nature of multimedia(More)
This study is part of research that is investigating the notion that human performance in dynamic and intentional decision making environments, such as ambulance dispatch management, can be improved if information is portrayed in a manner that supports the decision strategies invoked to achieve the goal states of the process being controlled. Hence, in(More)
We discuss the human role in hydropower system control, noting how it is different from other supervisory control environments and noting the typical shortcomings in current displays provided to hydropower system controllers. We describe steps towards evaluating proposed functional displays with industry hydropower controllers whose time with us was limited(More)
We describe a work domain analysis of a hydropower plant that operates in the two independent markets, the electricity market and the irrigation market. Based on the results of a work domain analysis, the authors develop configural displays that represent abstract functions of the hydropower system and that are intended as part of an ecological interface.(More)
We present a simulator of a hydropower company’s view of its scheme, and its broader market and network context, which has been developed to evaluate advanced displays for control room operations. Although simplified, the simulator captures all the main aspects of scheme operations. The simulator allows controlled studies to be performed that test the(More)