William A. Wallace

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Carbon nanotubes have distinctive characteristics, but their needle-like fibre shape has been compared to asbestos, raising concerns that widespread use of carbon nanotubes may lead to mesothelioma, cancer of the lining of the lungs caused by exposure to asbestos. Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate(More)
This paper presents a conceptual framework to define seismic resilience of communities and quantitative measures of resilience that can be useful for a coordinated research effort focusing on enhancing this resilience. This framework relies on the complementary measures of resilience: “Reduced failure probabilities,” “Reduced consequences from failures,”(More)
The objective of this paper is to provide a unified, theoretically grounded framework for trust in electronic environments. An overview of the research on trust is presented, examining the nature of the concept, its definition, and the factors and processes that contribute to trust. The result is an integrated model that provides a comprehensive framework(More)
Trust is an important yet complex and little understood aspect of the dyadic relationship between two entities. Trust plays an important role in the formation of coalitions in social networks and in determining how high value of information flows through the network. We present algorithmically quantifiable measures of trust based on communication behavior.(More)
1.1 An overview of the ILD guideline Since the publication of the first BTS guidelines for diffuse lung disease nearly 10 years ago, the specialty has seen considerable change. The early discussions of the Guideline Group centred upon whether the revised document might consist of the 1999 document with minor adaptations. However, it was considered that too(More)
BACKGROUND The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and high-risk atherosclerotic plaques using the radioactive tracers (18)F-sodium fluoride ((18)F-NaF)(More)
The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases, especially mesothelioma. Direct instillation of long and short CNTs into the pleural cavity, the site of mesothelioma development, produced asbestos-like length-dependent responses. The response to long(More)
BACKGROUND Glutathione S-transferases (GSTs) are involved in the detoxification of xenobiotics by conjugation with glutathione. One of the mu class genes of this superfamily of enzymes, GSTM1, is polymorphic because of a partial gene deletion. This results in a failure to express GSTM1 in approximately 50% of individuals. Several studies have linked GSTM1(More)
An enduring characteristic of emergencies is the need for near-simultaneous development and deployment of new management procedures. This need can arise with the onset of highly novel problems and the need to act quickly—factors which reduce opportunities for extensive planning in managing the emergency. As a result, decision makers in emergencies must be(More)