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Temporal profile of neuronal damage in a model of transient forebrain ischemia.

• William A Pulsinelli, J. B. Brierley, Fred Plum
• Annals of neurology
• 1982

This study examined the temporal profile of ischemic neuronal damage following transient bilateral forebrain ischemia in the rat model of four-vessel occlusion. Wistar rats were subjected to… (More)

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

• William A Pulsinelli, J. B. Brierley
• Stroke
• 1979

A new model of transient, bilateral hemispheric ischemia in the unanesthetized rat is described. During ether anesthesia the rat's vertebral arteries were electrocauterized through the alar foramina… (More)

Delayed hippocampal damage in humans following cardiorespiratory arrest.

• Carol K. Petito, Edward Feldmann, William A Pulsinelli, Fred Plum
• Neurology
• 1987

Transient ischemia in animals produces delayed cell death in vulnerable hippocampal neurons. To see if this occurs in humans, we reexamined brain slides from all patients with anoxic-ischemic… (More)

Dynamics of interstitial and intracellular pH in evolving brain infarct.

• Maiken Nedergaard, Richard P. Kraig, Juichi Tanabe, William A Pulsinelli
• The American journal of physiology
• 1991

We examined the relationships between intracellular pH (pHi) and interstitial pH (pHe) in a rat model of focal ischemia. Interstitial pH was measured with pH-sensitive microelectrodes, and the… (More)

Selective neuronal vulnerability: morphological and molecular characteristics.

• William A Pulsinelli
• Progress in brain research
• 1985

Acid-induced death in neurons and glia.

• Maiken Nedergaard, Steven A Goldman, Sudha Desai, William A Pulsinelli
• The Journal of neuroscience : the official…
• 1991

Lactic acidosis has been proposed to be one factor promoting cell death following cerebral ischemia. We have previously demonstrated that cultured neurons and glial are killed by relatively brief (10… (More)

Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries.

• Steven G. Brint, Michael Jacewicz, Marika Kiessling, Juichi Tanabe, William A Pulsinelli
• Journal of cerebral blood flow and metabolism…
• 1988

This article describes a 3-year experience with focal neocortical ischemia in three rat strains. Multiple groups of adult Wistar (n = 50), Fisher 344 (n = 31), and spontaneously hypertensive (n = 72)… (More)

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.

• Domenico E. Pellegrini-Giampietro, R Suzanne Zukin, Michael V. L. Bennett, Sunghee Cho, William A Pulsinelli
• Proceedings of the National Academy of Sciences…
• 1992

Severe, transient global ischemia of the brain induces delayed damage to specific neuronal populations. Sustained Ca2+ influx through glutamate receptor channels is thought to play a critical role in… (More)

Edema and vascular permeability in cerebral ischemia: comparison between ischemic neuronal damage and infarction.

• Carol K. Petito, William A Pulsinelli, George R. Jacobson, Fred Plum
• Journal of neuropathology and experimental…
• 1982

The respective influences of ischemic neuronal damage and infarction on the development of abnormal blood-brain barrier (BBB) permeability and cerebral edema were evaluated in a rat model of… (More)

Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus.

• William A Pulsinelli, David E. Levy, B. Sigsbee, Priscilla Scherer, Fred Plum
• The American journal of medicine
• 1983

Animal experiments employing controlled degrees of cerebral ischemia have demonstrated that elevated blood-brain glucose concentrations greatly enhance the extent and degree of subsequent brain… (More)

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