William A. Olsen

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A commercial alpha-amylase inhibitor with potent inhibitory activity in vitro was used in a randomized double-blind, cross-over clinical trial in six nonobese, healthy adult males. In these subjects, this inhibitor had no effect on the response of blood glucose, insulin, or breath hydrogen to a standardized starch meal. It is concluded that this formulation(More)
We used immune electron microscopy to study the intracellular localization of sucrase-isomaltase, an intrinsic glycoprotein of the brush border membrane, to provide insight regarding the sites of its synthesis and intracellular processing and the mechanisms of its transfer to the brush border membrane. We identified the protein by postembedding staining(More)
Diabetes stimulates the functional activity of the intestinal brush border membrane with enhancement of both hydrolytic enzyme activity and membrane transport systems. To determine the mechanism of this effect, we studied the effects of streptozotocin diabetes on the metabolism of one membrane protein, sucrase-isomaltase, which increases its activity in(More)
Recently TRW fielded a prototype system for a government customer. It provides a wide range of capabilities including data collection, hierarchical storage, automated distribution, data analysis, and product dissemination of imagery information. The system is capable of processing thousands of data sets and storing over 400 Gigabytes (GB) of data per day.(More)
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