Willi Bernhard

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All mammalian metallothioneins characterized contain a single polypeptide chain of 61 amino acid residues, among them 20 cysteines providing the ligands for seven metal-binding sites. Native metallothioneins are usually heterogeneous in metal composition, with Zn, Cd, and Cu occurring in varying proportions. However, forms containing only a single metal(More)
This article describes how a manufacturing system with working people can be modeled and simulated, wherein the focus is on the organizational processes of the people itself. Explanations are based on a real model, which was made for a Swiss Company producing weaving machines. The model described includes the assembly part where seven people with different(More)
Mammalian metallothioneins (MT) contain 20 Cys in a total of 61 amino acid residues and bind 7 Cd and/or Zn ions. The metal is localized in two clusters made up of three and four metal-thiolate complexes in the NH2- and COOH-terminal half of the chain, respectively [Otvos, J.D., & Armitage, I. M. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 7094-7098]. The(More)
In Switzerland, roundabouts enjoy a large and growing popularity. As a self-organizing system, they replace more and more the traditional traffic light systems. This article focuses on the modeling and simulation of a double tracked roundabout near Lucerne (Switzerland). The simulation results were used for decision purposes; in order to find out whether a(More)
This article describes the concept of a knowledge-based assistant (MASTER) for speeding up simulation projects. It is able to simulate and optimise whole enterprises of the types: discrete part-manufacturing, continuous process-manufacturing and service-companies. It consists of well proven, powerful software-packages, all of them are commercially(More)
Exposure of corn seedlings to high concentrations of Cd ions induces formation of large quantities of polypeptidic compounds which are composed almost exclusively of Glu, Cys and Gly and which bind Cd through thiolate coordination. These polymers occur in classes with molecular weights of 4000 and 8000, respectively, and are made up of chains of about 2000(More)
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