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BACKGROUND Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease. METHODS We first identified chromosomal loci that were strongly associated with coronary artery disease in the Wellcome Trust Case Control Consortium(More)
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse(More)
  • Nadeem Sarwar, Manjinder S Sandhu, Sally L Ricketts, Adam S Butterworth, Emanuele Di Angelantonio, S Matthijs Boekholdt +9 others
  • 2010
BACKGROUND Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality. METHODS We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride(More)
CONTEXT Walking speed is a fundamental parameter of human motion and is increasingly considered as an important indicator of individuals' health status. OBJECTIVE To evaluate the relationship of gait parameters, and demographic and physical characteristics in healthy men and women. DESIGN, SETTING, AND PARTICIPANTS Recruitment of a subsample (n = 358)(More)
Cellular development requires the precise control of gene expression states. Transcription factors are involved in this regulatory process through their combinatorial binding with DNA. Information about transcription factor binding sites can help determine which combinations of factors work together to regulate a gene, but it is unclear how far the binding(More)
  • Thomas McKerrell, Naomi Park, Thaidy Moreno, Carolyn S. Grove, Hannes Ponstingl, Jonathan Stephens +12 others
  • 2015
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequencing. Using only the hot spots studied, we identified clonal hemopoiesis in 0.8% of individuals under 60, rising to(More)
The segmentation of thrombus and vessel in microscopic image sequences is of high interest for identifying genes linked to cardiovascular diseases. This task is however challenging because of the low contrast and the highly dynamic conditions observed in time-lapse DIC in-vivo microscopic scenes. In this work, we introduce a probabilistic framework for the(More)