Willem M. de Vos

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Lactococcus lactis subsp. cremoris MG1363 is a paradigm strain for lactococci used in industrial dairy fermentations. However, despite of its importance for process development, no genome-scale metabolic model has been reported thus far. Moreover, current models for other lactococci only focus on growth and sugar degradation. A metabolic model that includes(More)
The members of the Lactobacillus genus are widely used in the food and feed industry and show a remarkable ecological adaptability. Several Lactobacillus strains have been marketed as probiotics as they possess health-promoting properties for the host. In the present study, we used two complementary next-generation sequencing technologies to deduce the(More)
While practised for over thousand years, there is presently a renaissance in the interest of using of faecal transplantations to modify the intestinal microbiota of patients. This clinical practice consists of delivering large amounts of bowel microbes in various forms into the intestinal tract of the recipient that usually has been cleared previously. The(More)
Financial support: Commission of the European Union through contract QLK1-CT-2000-01376 " Nutra Cells ". assessment of genetically modified microorganisms. Since these procedures are not yet implemented, the current risk assessment procedure is shared for GMOs derived from micro organisms, plants, or animals. At present, the use of organisms in food(More)
The lantibiotic nisin, produced by Lactococcus lactis, is an antimicrobiaI peptide characterized by the presence of three unsaturated amino acid side chains (two dehydroalanines and one dehydrobutyrine) and five (/3methyl)lanthionine rings, which are formed post-translationally. Nisin is widely used in the food industry as a preservative, since it inhibits(More)
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This is a Rome Working Team Report. All authors are responsible for study concept and design, acquisition of data, analysis and interpretation of data, and critical revision of the manuscript. Acknowledgement: The authors would like to thank Prof Willem de Vos, Prof Eamonn Quigley and the Rome Foundation board members for critical revision of the manuscript.