Willem Luyendijk

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An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloid angiopathy. Cloning and sequencing of the two exons that(More)
Clinical and neuropathological findings are reported in 63 patients with hereditary cerebral haemorrhage with amyloid angiopathy. Patients had mostly recurrent strokes, and at least 80% of these were haemorrhages. Almost a third of the patients died within a year of their first and only recorded haemorrhage, half of them within two weeks. This angiopathy(More)
This article describes 136 patients with hereditary cerebral haemorrhages; all patients belonged to families (originally) resident in Katwijk (The Netherlands). Cases of hereditary cerebral haemorrhage have also been reported in NW-Iceland, and in the Dutch coastal village of Scheveningen. Katwijk is a Dutch fishing-village, located 20 miles north of(More)
Hereditary cerebral hemorrhage with amyloidosis in Dutch patients is an autosomal dominant form of vascular amyloidosis restricted to the leptomeninges and cerebral cortex. Clinically the disease is characterized by cerebral hemorrhages leading to an early death. Immunohistochemical studies of five patients revealed that the vascular amyloid deposits(More)
A patient with paraplegia caused by spinal-cord compression due to extension into the spinal canal of angiomatous tissue from a haemangioma of the seventh dorsal vertebra, was treated, with good short-term objective results, by non-surgical (percutaneous catheter method) embolisation of the intercostal (osseous) arteries feeding the tumour. Embolisation of(More)
The arterial supply of the spinal cord of the rat in the thoracolumbar region was studied in 26 Wistar albino rats. Contrary to the situation in man, and in variance with earlier reports for the rat, we did not observe a single large artery at the thoracolumbar level supplying a large part of the spinal cord. The anterior spinal artery at this level seemed(More)
The authors report a case of homozygous thalassemia in which a mass of hematopoietic tissue in the vertebral canal caused spastic paraparesis. Surgical removal of the tissue plus radiotherapy were successful. The pathological findings indicated direct extension of hematopoietic tissue from the adjacent bone marrow into the epidural space of the vertebral(More)
Two cases of a spinal epidural meningiomas, one localized in the upper thoracic and the other in the cervico-thoracic region are presented. In the second case the tumour originated from the dural sac, i.e. the inner membrane of the developmentally double-layered spinal dura mater. In the first case, however, the tumour appeared to have arisen from the outer(More)