Willem Gijsbert van Panhuis

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Public health programs — especially vaccination programs — have led to dramatic declines in the incidence of contagious diseases in the United States over the past century.1-3 However, some contagious diseases are now on the rise despite the availability of vaccines. Pertussis vaccines have been available since the 1920s, but the worst pertussis epidemic(More)
BACKGROUND Currently, the only tests capable of determining the serotype associated with dengue virus (DENV) infection require sampling during the period of acute viremia. No test can accurately detect the serotype associated with past DENV infections. The standard assay for determination of serotype-specific antibody against DENV is the plaque reduction(More)
OBJECTIVES We investigated whether introducing the rotavirus and pneumococcal vaccines, which are greatly needed in West Africa, would overwhelm existing supply chains (i.e., the series of steps required to get a vaccine from the manufacturers to the target population) in Niger. METHODS As part of the Bill and Melinda Gates Foundation-funded Vaccine(More)
Dengue is a mosquito-transmitted virus infection that causes epidemics of febrile illness and hemorrhagic fever across the tropics and subtropics worldwide. Annual epidemics are commonly observed, but there is substantial spatiotemporal heterogeneity in intensity. A better understanding of this heterogeneity in dengue transmission could lead to improved(More)
BACKGROUND The use of high quality disease surveillance data has become increasingly important for public health action against new threats. In response, countries have developed a wide range of disease surveillance systems enabled by technological advancements. The heterogeneity and complexity of country data systems have caused a growing need for(More)
OBJECTIVE To assess the pattern of diseases in a natural disaster, which are not necessarily a direct consequence of the event but can impact on the way health assistance is to be provided. METHODS Cross-sectional, record-based study in the International Committee of the Red Cross field hospital in Aceh, Indonesia, established immediately after the(More)
BACKGROUND The human impact of the tsunami that occurred on 26 December 2004 was enormous, with Indonesia bearing a huge proportion of the losses. The aftermath brought predictions of communicable disease outbreaks and widespread fear of epidemics. However, evidence from previous disasters due to natural hazards does not support all of these predictions.(More)
Armed conflicts are defined as political conflicts in which armed combat involves the armed forces of at least one state or one or more armed factions seeking to gain control of all or part of the state, and in which at least 1,000 people have been killed by the fighting during the course of the conflict. Globally, the number of armed conflicts has been(More)
BACKGROUND Many countries, such as Niger, are considering changing their vaccine vial size presentation and may want to evaluate the subsequent impact on their supply chains, the series of steps required to get vaccines from their manufacturers to patients. The measles vaccine is particularly important in Niger, a country prone to measles outbreaks. (More)
Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects(More)