Willem D. van Driel

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Nuclear factor I is a 47-kd protein, isolated from nuclei of HeLa cells, that binds specifically to the inverted terminal repeat of the adenovirus (Ad) DNA and enhances Ad DNA replication in vitro. We have studied the DNA sequence specificity of nuclear factor I binding using cloned terminal fragments of the Ad2 genome and a set of deletion mutants. Binding(More)
Employing an exonuclease III protection assay we detected a protein in crude HeLa nuclear extracts binding, with apparent sequence specificity, to molecular ends of adenovirus type 2 (Ad2) DNA. This protein, designated nuclear factor IV (NFIV), was purified to homogeneity and was shown to be a hetero-dimer of 72,000 and 84,000 Mr. Binding to terminal Ad2(More)
Due to their long lifetime and high efficacy, solid state lighting (SSL) has the potential to revolutionize the illumination industry. The long lifetime claimed by the manufacturers is often based solely on the estimated depreciation of lumen for a single LED operating at 25°C. However, self heating and high environmental temperature which will lead(More)
Interface delamination is one of the most important issues in the microelectronic packaging industry. Silver filled die attach is a typical adhesive used between the die and copper die pad for its improved heat dissipation capacity. Delamination between die attach and die pad will severely impact the heat conduction and result in product failure. In order(More)
The non-ideal nature of package level interconnects gives rise to issues such as crosstalk induced noise and simultaneous switching noise which affect the reliable operation of high performance digital systems. We examine the causes of various signal losses that occur in the package level interconnect, and with an equivalent circuit model, highlight the(More)
This paper describes a new design concept of automatically diagnosing and compensating LED degradations in distributed solid state lighting (SSL) systems. A failed LED may significantly reduce the overall illumination level, and destroy the uniform illumination distribution achieved by a nominal system. To our knowledge, an automatic scheme to compensate(More)
Growth and heavy-metal uptake of various food crops and grass cultivated on harbour dredge spoils were studied, and health aspects in consuming the marketable products were discussed. Vegetables (potato, carrot, radish, endive, lettuce) and grass (English ryegrass) performed well on dredge spoils, but small grains (wheat, barley) were affected by manganese(More)
As the market demand of high power, high frequency and high efficiency, the advanced RF power packaging and assembly technology is facing the challenge of new material and new design. Improving the thermal conductivity of the heatsink (flange) is one of the effective ways to obtain low thermal resistance (Rth) component. Compared to the silicon transistors,(More)
Nuclear factor I (NFI) is a HeLa sequence-specific DNA-binding protein that is required for initiation of adenovirus (Ad) DNA replication and may be involved in the expression of several cellular genes. The interaction between NFI and its binding site on the Ad2 origin has been studied. Methylation interference and protection, u.v. irradiation of 5-BrdU(More)
As the market demands for high power and high efficiency power electronics, the industries has developed advanced IC technology and conceptual configuration. However, in order to guarantee the performance and reliability of the power electronics, the challenge of the packaging arises.