Willem BGJ Hamersma

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In exercise testing of patients with chronic obstructive pulmonary disease (COPD), non-invasive assessment of stroke volume (SV) and cardiac output (CO) would be valuable. Electrical impedance cardiography (EIC) has proved to be a valid and reliable instrument in healthy subjects. In this study it is investigated whether this also applies to patients with(More)
Objective: To investigate the relative efficacy of three inhalers containing salbutamol: Turbuhaler (TBH), Rotahaler (RH) and Diskhaler (DH). Methods: A randomized, open, three-way crossover, cumulative dose response study was performed in 20 patients with asthma with mean forced expiratory volume in 1s (FEV1) values of 60% of predicted (range 41–90%) and a(More)
OBJECTIVES During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates(More)
BACKGROUND Exercise intolerance (EI) in systemic sclerosis (SSc) is difficult to manage by the clinician. The peripheral chemoreflex drive compensates for metabolic acidosis during exercise and may be related to EI. AIM To assess the global peripheral chemoreflex drive (GPCD) in patients with SSc at rest and during exercise. METHODS Consecutively tested(More)
BACKGROUND Dyspnea may be a presenting symptom in progressive systemic sclerosis (SSc). Respiratory drive (mouth occlusion pressure, MOP, at rest and during CO2 rebreathing, 7% CO2, 93% O2) is a major determinant of dyspnea and may relate to the magnitude of dyspnea. METHODS In a prospective design, MOP at 0.1 sec (P0.1) was measured in 73 SSc patients(More)
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