Willem Albers

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Tail alternatives describe the frequent occurrence of a non-constant shift in the two-sample problem with a shift function increasing in the tail. The classes of shift functions can be built up using Legendre polynomials. It is important to rightly choose the number of involved polynomials. Here this choice is based on the data, using a modification of(More)
Fu Xiang Wang,1 Francisco J. Rodríguez,1 Willem M. Albers,2 Risto Ahorinta,3 J. E. Sipe,4 and Martti Kauranen1,* 1Department of Physics, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere, Finland 2VTT Microtechnology and Sensors, P.O. Box 1300, FI-33101 Tampere, Finland 3Optoelectronics Research Centre, Tampere University of Technology, P.O.(More)
The influence of the estimation of parameters in Shewhart control charts is investigated. It is shown by simulation and asymptotics that (very) large sample sizes are needed to accurately determine control charts if estimators are plugged in. Correction terms are developed to get accurate control limits for common sample sizes in the in-control situation.(More)
Lipoate derivatives were used for the formation of imprinted self-assembled molecular thin films for the recognition of morphine. A large collection of lipoate derivatives was screened by molecular dynamics simulations in various solvents. A set of ligands showing favourable interactions with morphine in aqueous environment was selected for synthesis.(More)
Recombinant anti-morphine Fab' fragments have been immobilised on gold by covalent attachment through the free thiol groups of the fragment. The antibody fragments were intercalated with a non-ionic hydrophilic polymer in order to suppress non-specific binding of interfering substances. The antibodies are oriented on the surface due to the thiol groups of(More)
Standard control charts are based on the assumption that the observations are normally distributed. In practice, normality often fails and consequently the false alarm rate is seriously in error. Application of a nonparametric approach is only possible with many Phase I observations. Since nowadays such very large sample sizes are usually not available,(More)
Standard control chart practice assumes normality and uses estimated parameters. Because of the extreme quantiles involved, large relative errors result. Here simple corrections are derived to bring such estimated charts under control. As a criterion, suitable exceedance probabilities are used.
C-reactive protein, CRP antibody Fab'-fragments have been attached on pre-cleaned gold slides and protein repellent polymers have been used to block the remaining free space in between the antibody fragments. At optimal conditions the antibody fragments are site-directly immobilised on the surface and non-specific binding is reduced. The amount of(More)