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CONTEXT In the United States, young people aged 15-24 represent 25% of the sexually experienced population. However, the incidence and prevalence of sexually transmitted diseases (STDs) among this age-group are unknown. METHODS Data from a variety of sources were used to estimate the incidence and prevalence of STDs among 15-24-year-olds in the United(More)
OBJECTIVES The objective of this trial was to investigate the safety and preliminary effectiveness of a daily dose of 300 mg of tenofovir disoproxil fumarate (TDF) versus placebo in preventing HIV infection in women. DESIGN This was a phase 2, randomized, double-blind, placebo-controlled trial. SETTING The study was conducted between June 2004 and March(More)
The World Health Organisation sponsored a multicentre, collaborative investigation of a standard approach to evaluating infertile couples. The study was conducted between 1979 and 1984 in thirty-three medical centres in twenty-five countries throughout the developed and developing world. Over 5800 couples completed the investigation. African centres had a(More)
Universal voluntary HIV testing and immediate antiretroviral therapy In Reuben Granich and colleagues' mathematical model on the benefi ts of antiretroviral therapy for HIV prevention (Jan 3, p 48), 1 everyone is tested and everyone with HIV is treated immediately (irrespective of CD4+ cell count). However, the relation of this theoretical model to reality(More)
Sex work occurs in many forms and sex workers of all genders have been affected by HIV epidemics worldwide. The determinants of HIV risk associated with sex work occur at several levels, including individual biological and behavioural, dyadic and network, and community and social environmental levels. Evidence indicates that effective HIV prevention(More)